Association of endothelial nitric oxide synthase (eNOS) gene polymorphisms and physical fitness levels with plasma nitrite concentrations and arterial blood pressure values in older adults

Autor(es)

da Silva, Roberta Fernanda ^[1] ; Trape, Atila Alexandre ^[2] ; Reia, Thais Amanda ^[1] ; Lacchini, Riccardo ^[2] ; Oliveira-Paula, Gustavo Henrique ^[3] ; Pinheiro, Lucas Cezar ^[3] ; Tanus-Santos, Jose Eduardo ^[3] ; Jacomini, Andre Mourao ^[1] ; Bueno Junior, Carlos Roberto ^[2] ; Zago, Anderson Saranz ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Dept Phys Educ, Sch Sci, Bauru, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 13, n. 10 OCT 18 2018.
• Citações Web of Science: 0

Resumo

Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differences that physical exercise can be performed, some controversial results are found. Therefore it seems reasonable to evaluate the training status (TS). Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. 424 elderly performed the following assessments: General Functional Fitness Index (GFFI) to estimate TS, systolic and diastolic blood pressure (SBP and DBP), blood collection for analysis of NO2- and g.-786T>C, intron 4b/a (VNTR) and 894G>T polymorphisms. Multivariate logistic regression showed that NO2- was influenced by GFFI and 4b/4a Intron 4. Regarding BP, GFFI influenced SBP and DBP, and just intron 4 was associated with variations in DBP. It can be observed that GFFI affected the NO2-, SBP and DBP independently of haplotypes. Therefore, maintenance of good level of TS can overcome the negative influence of genetics factors (intron 4) by increasing NO2- concentration and decreasing BP values. (AU)

• Processo FAPESP: 15/24847-8 - Variação dos mecanismos de regulação da pressão arterial durante a realização do exercício físico agudo em adultos e idosos, hipertensos e normotensos e com diferentes níveis de condicionamento físico
• Beneficiário: Anderson Saranz Zago
• Modalidade de apoio: Auxílio à Pesquisa - Regular