| Full text | |
| Author(s): |
da Silva, Roberta Fernanda
[1]
;
Trape, Atila Alexandre
[2]
;
Reia, Thais Amanda
[1]
;
Lacchini, Riccardo
[2]
;
Oliveira-Paula, Gustavo Henrique
[3]
;
Pinheiro, Lucas Cezar
[3]
;
Tanus-Santos, Jose Eduardo
[3]
;
Jacomini, Andre Mourao
[1]
;
Bueno Junior, Carlos Roberto
[2]
;
Zago, Anderson Saranz
[1]
Total Authors: 10
|
| Affiliation: | [1] Sao Paulo State Univ UNESP, Dept Phys Educ, Sch Sci, Bauru, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Coll Nursing, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | PLoS One; v. 13, n. 10 OCT 18 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with reduced eNOS activity and nitric oxide (NO) production leading to an increase in blood pressure (BP). Regular exercise is the main strategy to minimize the deleterious effects of polymorphisms. However, due to the differences that physical exercise can be performed, some controversial results are found. Therefore it seems reasonable to evaluate the training status (TS). Thus, this study aimed to investigate the association of eNOS gene haplotypes and different levels of TS on nitrite concentrations (NO2-) and BP values in older adult. 424 elderly performed the following assessments: General Functional Fitness Index (GFFI) to estimate TS, systolic and diastolic blood pressure (SBP and DBP), blood collection for analysis of NO2- and g.-786T>C, intron 4b/a (VNTR) and 894G>T polymorphisms. Multivariate logistic regression showed that NO2- was influenced by GFFI and 4b/4a Intron 4. Regarding BP, GFFI influenced SBP and DBP, and just intron 4 was associated with variations in DBP. It can be observed that GFFI affected the NO2-, SBP and DBP independently of haplotypes. Therefore, maintenance of good level of TS can overcome the negative influence of genetics factors (intron 4) by increasing NO2- concentration and decreasing BP values. (AU) | |
| FAPESP's process: | 15/24847-8 - Comparative analysis of the mechanisms involved in the regulation of blood pressure during acute physical exercise in adults and elderly, hypertensive and normotensive and individuals with different level of training status |
| Grantee: | Anderson Saranz Zago |
| Support Opportunities: | Regular Research Grants |