Investigation of thermal degradation products of mebendazole by thermal and spectroscopic analysis

Autor(es)

Holanda, Bruno B. C. ^[1] ; Alarcon, Rafael T. ^[1] ; Guerra, Renan B. ^[1] ; Rinaldo, Daniel ^[1] ; Spazzini, Fabiola C. R. ^[1] ; Castro, Ricardo A. E. ^[2] ; Bannach, Gilbert ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Sch Sci, Chem Dept, BR-17033260 Bauru, SP - Brazil

^[2] Coimbra Univ, Coll Pharm, P-3000578 Coimbra - Portugal

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS; v. 135, p. 76-84, OCT 2018.
• Citações Web of Science: 3

Resumo

In this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved gas analysis (EGA), and DSC-photovisual analysis were employed to fully evaluate the polymorphic form A of MBZ. Our results showed that mebendazole undergoes mass loss starting at 205 degrees C with the release of methanol and carbon monoxide. Characterization of the main thermal decomposition product of MBZ through mid-infrared spectroscopy (MIR), proton nuclear magnetic resonance (H-1 NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and powder X-ray diffraction (PXRD) indicated the formation of 2-amino-5-benzoylbenzimidazole (MBZ-A). Kinetic parameters for MBZ and MBZ-A were also evaluated and shown herein. (AU)

• Processo FAPESP: 18/03460-6 - Modificação estrutural de triglicerídeos visando a obtenção de novos monômeros e polímeros por diferentes rotas sintéticas: irradiação de micro-ondas e fotopolimerização
• Beneficiário: Rafael Turra Alarcon
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/08820-8 - Síntese e caracterização de biopolímeros a partir de óleos vegetais e glicerol seguindo os princípios da química verde.
• Beneficiário: Gilbert Bannach
• Modalidade de apoio: Auxílio à Pesquisa - Regular