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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Investigation of thermal degradation products of mebendazole by thermal and spectroscopic analysis

Full text
Author(s):
Holanda, Bruno B. C. [1] ; Alarcon, Rafael T. [1] ; Guerra, Renan B. [1] ; Rinaldo, Daniel [1] ; Spazzini, Fabiola C. R. [1] ; Castro, Ricardo A. E. [2] ; Bannach, Gilbert [1]
Total Authors: 7
Affiliation:
[1] UNESP Sao Paulo State Univ, Sch Sci, Chem Dept, BR-17033260 Bauru, SP - Brazil
[2] Coimbra Univ, Coll Pharm, P-3000578 Coimbra - Portugal
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS; v. 135, p. 76-84, OCT 2018.
Web of Science Citations: 3
Abstract

In this work, the thermal decomposition of mebendazole (MBZ) was studied to elucidate divergent data found in the literature concerning the thermal behavior of this drug. To this end, thermogravimetry-differential scanning calorimetry (TG-DSC), differential scanning calorimetry (DSC), evolved gas analysis (EGA), and DSC-photovisual analysis were employed to fully evaluate the polymorphic form A of MBZ. Our results showed that mebendazole undergoes mass loss starting at 205 degrees C with the release of methanol and carbon monoxide. Characterization of the main thermal decomposition product of MBZ through mid-infrared spectroscopy (MIR), proton nuclear magnetic resonance (H-1 NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and powder X-ray diffraction (PXRD) indicated the formation of 2-amino-5-benzoylbenzimidazole (MBZ-A). Kinetic parameters for MBZ and MBZ-A were also evaluated and shown herein. (AU)

FAPESP's process: 18/03460-6 - Structural modification of triglycerides aiming new monomers and polymers, using different synthetic routes: microwave irradiation and photopolymerization
Grantee:Rafael Turra Alarcon
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/08820-8 - Synthesis and characterization of biopolymers from vegetable oils and glycerol following the principles of green chemistry
Grantee:Gilbert Bannach
Support Opportunities: Regular Research Grants