Effect of curcumin on bone tissue in the diabetic rat: repair of peri-implant and critical-sized defects

Autor(es)

Cirano, F. R. ^[1] ; Pimentel, S. P. ^[1] ; Casati, M. Z. ^[1] ; Correa, M. G. ^[1] ; Pino, D. S. ^[1] ; Messora, M. R. ^[2] ; Silva, P. H. F. ^[2] ; Ribeiro, F. V. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Paulista, Sch Dent, Dent Res Div, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Ribeirao Preto Sch Dent, Dept Surg & Buccomaxillofacial Traumatol & Period, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Oral and Maxillofacial Surgery; v. 47, n. 11, p. 1495-1503, NOV 2018.
• Citações Web of Science: 1

Resumo

This study determined the effect of curcumin on bone healing in animals with diabetes mellitus (DM). One hundred rats were divided into five groups: DM + PLAC, DM + CURC, DM + INS, DM + CURC + INS, and non-DM (CURC, curcumin; PLAC, placebo; INS, insulin). Critical calvarial defects were created and titanium implants were inserted into the tibiae. Calvarial defects were analyzed histometrically, and BMP-2, OPN, OPG, RANKL, Runx2, Osx, beta-catenin, Lrp-5, and Dkk1 mRNA levels were quantified by PCR. The implants were removed for a torque evaluation, the peri-implant tissue was collected for mRNA quantification of the same bone-related markers, and the tibiae were submitted to micro-computed tomography. The DM + CURC + INS and non-DM groups exhibited greater closure of the calvaria when compared to the DM + PLAC group (P < 0.05). Increased retention of implants was observed in the DM + CURC, DM + CURC + INS, and non-DM groups when compared to the DM + PLAC group (P < 0.05). CURC improved bone volume and increased bone-implant contact when compared to DM + PLAC (P < 0.05). In calvarial samples, CURC favourably modulated RANKL/OPG and Dkk1 and improved beta-catenin levels when compared to DM + PLAC (P < 0.05). In peri-implant samples, Dkk1 and RANKL/OPG were down-regulated and BMP-2 up-regulated by CURC when compared to DM + PLAC (P < 0.05). CURC reverses the harmful effects of DM in bone healing, contributing to the modulation of bone-related markers. (AU)

• Processo FAPESP: 14/09480-8 - Impacto do resveratrol em condições de risco: avaliação dos processos de reparo ósseo e da periodontite experimental induzida em ratos diabéticos e expostos à fumaça do cigarro
• Beneficiário: Fernanda Vieira Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular