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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of curcumin on bone tissue in the diabetic rat: repair of peri-implant and critical-sized defects

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Author(s):
Cirano, F. R. [1] ; Pimentel, S. P. [1] ; Casati, M. Z. [1] ; Correa, M. G. [1] ; Pino, D. S. [1] ; Messora, M. R. [2] ; Silva, P. H. F. [2] ; Ribeiro, F. V. [1]
Total Authors: 8
Affiliation:
[1] Univ Paulista, Sch Dent, Dent Res Div, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Dent, Dept Surg & Buccomaxillofacial Traumatol & Period, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Oral and Maxillofacial Surgery; v. 47, n. 11, p. 1495-1503, NOV 2018.
Web of Science Citations: 1
Abstract

This study determined the effect of curcumin on bone healing in animals with diabetes mellitus (DM). One hundred rats were divided into five groups: DM + PLAC, DM + CURC, DM + INS, DM + CURC + INS, and non-DM (CURC, curcumin; PLAC, placebo; INS, insulin). Critical calvarial defects were created and titanium implants were inserted into the tibiae. Calvarial defects were analyzed histometrically, and BMP-2, OPN, OPG, RANKL, Runx2, Osx, beta-catenin, Lrp-5, and Dkk1 mRNA levels were quantified by PCR. The implants were removed for a torque evaluation, the peri-implant tissue was collected for mRNA quantification of the same bone-related markers, and the tibiae were submitted to micro-computed tomography. The DM + CURC + INS and non-DM groups exhibited greater closure of the calvaria when compared to the DM + PLAC group (P < 0.05). Increased retention of implants was observed in the DM + CURC, DM + CURC + INS, and non-DM groups when compared to the DM + PLAC group (P < 0.05). CURC improved bone volume and increased bone-implant contact when compared to DM + PLAC (P < 0.05). In calvarial samples, CURC favourably modulated RANKL/OPG and Dkk1 and improved beta-catenin levels when compared to DM + PLAC (P < 0.05). In peri-implant samples, Dkk1 and RANKL/OPG were down-regulated and BMP-2 up-regulated by CURC when compared to DM + PLAC (P < 0.05). CURC reverses the harmful effects of DM in bone healing, contributing to the modulation of bone-related markers. (AU)

FAPESP's process: 14/09480-8 - Impact of resveratrol in risk conditions: evaluation of bone repair processess and of experimental periodontitis in diabectic and smoking rats
Grantee:Fernanda Vieira Ribeiro
Support Opportunities: Regular Research Grants