Towards the production of natural rubber-calcium phosphate hybrid for applications as bioactive coatings

Autor(es)

do Nascimento, Rodney Marcelo ^[1] ; de Paula, Amauri Jardim ^[2] ; Oliveira, Naiara Cipriano ^[2] ; Alves, Ana Cecilia ^[2] ; Lima de Oliveira Aquino, Yasmine Maria ^[2] ; Souza Filho, Antonio Gomes ^[2] ; Figueiredo Soares Rodrigues, Joao Elias ^[1] ; Hernandes, Antonio Carlos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, POB 369, BR-13566590 Sao Carlos, SP - Brazil

^[2] Univ Fed Ceara, Dept Fis, POB 6030, BR-60455900 Fortaleza, CE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Science & Engineering C-Materials for Biological Applications; v. 94, p. 417-425, JAN 1 2019.
• Citações Web of Science: 0

Resumo

This paper assesses the morphological, structural and bio-physicochemical stability of natural rubber (NR) Hevea brasiliensis coatings incorporated with microparticles of calcium phosphate-based (CaP) bioactive ceramics. Optical and electronic spectroscopic imaging techniques were employed to successfully evaluate the NR encapsulation capability and the stability of the coating in a biologically relevant media for bio-related application, i.e., simulated body fluid (SBF). The chemical structure of the natural polymer, the microchemical environment at the NR-CaP interface and the morphology of the CaP clusters were fully characterized. Further, the response of the hybrid coating to SBF was evaluated by incubating the samples for 30 days. The hybrid coating formed on Si surface (inert substrate) exhibited both stability and biodegradability in different levels (time dependence), thus opening horizons for applications as coatings for both biomaterials and drug delivery systems. (AU)

• Processo FAPESP: 13/21970-8 - Desenvolvimento de biomaterial a partir da incorporação de fosfatos de cálcio em estruturas de látex visando aplicação como dispositivo de liberação controlada
• Beneficiário: Rodney Marcelo do Nascimento
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado