| Texto completo | |
| Autor(es): |
Monteiro, D. A.
[1]
;
Kalinin, A. L.
[1]
;
Selistre-de-Araujo, H. S.
[1]
;
Nogueira, L. A. N.
[2]
;
Beletti, M. E.
[2]
;
Fernandes, M. N.
[1]
;
Rantin, F. T.
[1]
Número total de Autores: 7
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil
[2] Univ Fed Uberlandia, Inst Biomed Sci, Uberlandia, MG - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 215, p. 67-75, JAN 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Alternagin-C (ALT-C) is a disintegrin-like peptide purified from Rhinocerophis alternatus snake venom with the property of inducing vascular endothelial growth factor (VEGF) expression, endothelial cell proliferation and migration, and angiogenesis. Therefore, this protein could be interesting as a new approach for ischemic heart diseases, an imbalance between myocardial oxygen supply and demand, leading to cardiac dysfunction. We investigated the effects of a single dose of altemagin-C (0.5 mg kg(-1), via intra-arterial), after 7 days, on hypoxia/reoxygenation challenge in isolated ventricle strips and on morphological changes and density of blood vessels of the heart, using fish as an alternative experimental model. ALT-C treatment provided protection of cardiomyocytes against hypoxia/reoxygenation-induced negative inotropism. ALT-C also stimulated angiogenesis and improved excitation-contraction coupling during hypoxic conditions. Our results provide a new insight into a functional role of ALT-C against hypoxia/reoxygenation-induced cardiomyocyte injury pointing out to a potential therapeutic strategy for ischemia-related diseases. (AU) | |
| Processo FAPESP: | 12/10993-4 - Efeitos da alternagina-C (ALT-C), uma proteína extraída do veneno da serpente Urutu (Rhinocerophis alternatus, antiga Bothrops alternatus), sobre a contratilidade cardíaca de peixe em normóxia e frente à hipóxia tecidual |
| Beneficiário: | Diana Amaral Monteiro |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 13/00798-2 - A matriz extracelular no envelhecimento, no exercício e no microambiente tumoral |
| Beneficiário: | Heloisa Sobreiro Selistre de Araújo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |