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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardioprotective effects of alternagin-C (ALT-C), a disintegrin-like protein from Rhinocerophis alternatus snake venom, on hypoxia-reoxygenation-induced injury in fish

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Author(s):
Monteiro, D. A. [1] ; Kalinin, A. L. [1] ; Selistre-de-Araujo, H. S. [1] ; Nogueira, L. A. N. [2] ; Beletti, M. E. [2] ; Fernandes, M. N. [1] ; Rantin, F. T. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Carlos, Dept Physiol Sci, Sao Carlos, SP - Brazil
[2] Univ Fed Uberlandia, Inst Biomed Sci, Uberlandia, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY; v. 215, p. 67-75, JAN 2019.
Web of Science Citations: 0
Abstract

Alternagin-C (ALT-C) is a disintegrin-like peptide purified from Rhinocerophis alternatus snake venom with the property of inducing vascular endothelial growth factor (VEGF) expression, endothelial cell proliferation and migration, and angiogenesis. Therefore, this protein could be interesting as a new approach for ischemic heart diseases, an imbalance between myocardial oxygen supply and demand, leading to cardiac dysfunction. We investigated the effects of a single dose of altemagin-C (0.5 mg kg(-1), via intra-arterial), after 7 days, on hypoxia/reoxygenation challenge in isolated ventricle strips and on morphological changes and density of blood vessels of the heart, using fish as an alternative experimental model. ALT-C treatment provided protection of cardiomyocytes against hypoxia/reoxygenation-induced negative inotropism. ALT-C also stimulated angiogenesis and improved excitation-contraction coupling during hypoxic conditions. Our results provide a new insight into a functional role of ALT-C against hypoxia/reoxygenation-induced cardiomyocyte injury pointing out to a potential therapeutic strategy for ischemia-related diseases. (AU)

FAPESP's process: 12/10993-4 - Effects of alternagin-C (ALT-C), a protein from venom of urutu snake (Rhinocerophis alternatus, previously known Bothrops alternatus), on fish cardiac contractility under normoxia and against tissue hypoxia
Grantee:Diana Amaral Monteiro
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/00798-2 - The extracellular matrix in aging, exercise and in the tumor microenvironment
Grantee:Heloisa Sobreiro Selistre de Araújo
Support Opportunities: Research Projects - Thematic Grants