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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Single aggressive and non-aggressive social interactions elicit distinct behavioral patterns to the context in mice

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Autor(es):
Crestani, Ariela M. [1, 2] ; Cipriano, Ana C. [1, 2] ; Nunes-de-Souza, Ricardo L. [1, 2]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci, Sao Paulo - Brazil
[2] Univ Estadual Paulista, Joint Grad Program Physiol Sci, UFSCar, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Behavioural Processes; v. 157, p. 601-609, DEC 2018.
Citações Web of Science: 0
Resumo

Aggressive interactions between conspecific animals have been used as a social stressor with ethological characteristics to study how social interactions can modulate animal's behavior. Here, a new protocol based on aggressive and non-aggressive interactions was developed to study how different social interactions can alter the behavioral profile of animals re-exposed to the context in which the interaction occurred. We used factor analysis to trace the behavioral profile of socially defeated and non-defeated mice when they were re-exposed to the apparatus {[}three interconnected chambers: home chamber, tunnel and surface area]; we also compared the behavior presented before (habituation) and 24 h after (re-exposure) the non-aggressive or aggressive interactions. A final factor analysis from defeated animals yielded 4 factors that represented 72.09% of total variance; whereas non-defeated animal's analysis was loaded with 5 factors that represented 85.46% of total variance. A 5-min non-aggressive interaction reduced the frequency of stretched attend behavior in the tunnel, whereas a single social defeat reduced time in the tunnel and increased time spent performing self-grooming in the home chamber without conditioning any other spatio-temporal and complementary measures. Together, these results suggest that different social interactions may modulate distinct behavioral profiles in animals when re-exposed to the context. (AU)

Processo FAPESP: 11/04561-1 - Avaliação neuropsicofarmacológica dos mecanismos Crf-érgicos na amídala, nas reações de defesa de camundongos pré-expostos à derrota social
Beneficiário:Ana Cláudia Cipriano
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto