Oestrogen receptor alpha, growth hormone receptor, and developmental defect of enamel

Autor(es)

Arid, Juliana ^[1] ; Oliveira, Daniela B. ^[2] ; Evangelista, Silvane S. ^[1] ; Vasconcelos, Katia R. F. ^[1] ; Dutra, Andre L. T. ^[3] ; de Oliveira, Sara S. ^[3] ; de Queiroz, Alexandra M. ^[1] ; Nelson-Filho, Paulo ^[1] ; Vieira, Alexandre R. ^[4] ; Kuchler, Erika C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Pediat Dent, Ribeirao Preto, SP - Brazil

^[2] Univ Fed Alfenas, Dept Pediat Dent, Alfenas, MG - Brazil

^[3] State Univ Amazonas, Dept Dent, Manaus, Amazonas - Brazil

^[4] Univ Pittsburgh, Sch Dent Med, Dept Oral Biol, Pittsburgh, PA - USA

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Paediatric Dentistry; v. 29, n. 1, p. 29-35, JAN 2019.
• Citações Web of Science: 0

Resumo

Background Oestrogen (ES) and growth hormone (GH) are hormones that may have a role in caries aetiology and developmental defects of enamel (DDE) since their receptors (ERs and GHR) are expressed during amelogenesis. Aim To evaluate whether genetic polymorphisms in the genes that codify the ER alpha (ESR1) and GHR are associated with caries experience and DDE in children. Design Two hundred and sixteen children of both genders, aged 9-12 years, were examined and classified according to caries and DDE phenotype. Genomic DNA was extracted from buccal cells in saliva. Genetic polymorphisms in ERS1 (rs1884051 and rs12154178) and GHR (rs297305, rs2940913, rs2910875, and rs1509460) were genotyped using TaqMan chemistry. Data were analysed by PLINK, while the chi-square test was used to compare allele and genotype distributions (alpha of 5%). Results A total of 131 children (60.7%) had caries experience, and 43 (19.9%) presented DDE. Genotype and allele distributions were not associated with caries experience (P > 0.05). Genotype and allele distributions between DDE, affected and unaffected, were associated with the polymorphism rs12154178 in ESR1 (P = 0.01 and P = 0.001, respectively) and with the polymorphism rs1509460 in GHR (P = 0.05 and P = 0.02, respectively). Conclusions Genetic polymorphisms in ERS1 (rs12154178) and GHR (rs1509460) are associated with DDE. (AU)

• Processo FAPESP: 15/06866-5 - Avaliação do papel do estrógeno no desenvolvimento dentofacial
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores