A review of select minerals influencing the haematopoietic process

Autor(es)

Oliveira, Dalila Cunha ^[1] ; Nogueira-Pedro, Amanda ^[1] ; Santos, Ed Wilson ^[1] ; Hastreiter, Araceli ^[1] ; Silva, Graziela Batista ^[1] ; Borelli, Primavera ^[1] ; Fock, Ricardo Ambrosio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Analyses, Expt Hematol Lab, BR-05508900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRITION RESEARCH REVIEWS; v. 31, n. 2, p. 267-280, DEC 2018.
• Citações Web of Science: 4

Resumo

Micronutrients are indispensable for adequate metabolism, such as biochemical function and cell production. The production of blood cells is named haematopoiesis and this process is highly consuming due to the rapid turnover of the haematopoietic system and consequent demand for nutrients. It is well established that micronutrients are relevant to blood cell production, although some of the mechanisms of how micronutrients modulate haematopoiesis remain unknown. The aim of the present review is to summarise the effect of Fe, Mn, Ca, Mg, Na, K, Co, iodine, P, Se, Cu, Li and Zn on haematopoiesis. This review deals specifically with the physiological requirements of selected micronutrients to haematopoiesis, showing various studies related to the physiological requirements, deficiency or excess of these minerals on haematopoiesis. The literature selected includes studies in animal models and human subjects. In circumstances where these minerals have not been studied for a given condition, no information was used. All the selected minerals have an important role in haematopoiesis by influencing the quality and quantity of blood cell production. In addition, it is highly recommended that the established nutrition recommendations for these minerals be followed, because cases of excess or deficient mineral intake can affect the haematopoiesis process. (AU)

• Processo FAPESP: 16/16463-8 - Avaliação dos efeitos moduladores e mecanismos do fragmento sintético da leptina LEP 5 na regulação da hematopoiese em camundongos submetidos à desnutrição protéica
• Beneficiário: Ricardo Ambrósio Fock
• Modalidade de apoio: Auxílio à Pesquisa - Regular