Photobiomodulation modulates the resolution of inflammation during acute lung injury induced by sepsis

Autor(es)

da-Palma-Cruz, Marlon ^[1] ; da Silva, Rodrigo Fernando ^[1] ; Monteiro, Dhuane ^[1] ; Rehim, Hassan Mohamed Mohamed Abdel ^[1] ; Grabulosa, Caren Cristina ^[1] ; Ligeiro de Oliveira, Ana Paula ^[1] ; Lino-dos-Santos-Franco, Adriana ^[1]

Afiliação do(s) autor(es)

^[1] Univ Nove Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Rua Vergueiro 239-245, BR-01504000 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lasers in Medical Science; v. 34, n. 1, p. 191-199, FEB 2019.
• Citações Web of Science: 1

Resumo

Sepsis is a big health problem and one of the most common causes of acute lung injury (ALI) leading to high mortality. Pro-resolving mediators play an important role in abrogating the inflammation and promoting tissue homeostasis restoration. ALI treatment is still a clinical health problem, so new therapies are needed. Here, we evaluated the effect of photobiomodulation treatment on the resolution process of ALI induced by lipopolysaccharide (LPS). Male Balb/c mice were submitted to LPS (ip) or vehicle and irradiated or not with light emitting diode (LED) 2 and 6h after LPS or vehicle injection, and the parameters were investigated 3 and 7days after the injections. Our results showed that after 3days of LED treatment the blood and bronchoalveolar lavage (BAL) cells as well as interleukins (IL) including IL-6 and IL-17 were reduced. No differences were observed in the bone marrow cells, tracheal reactivity, and lipoxin A4 and resolvin E2. Indeed, after 7days of LED treatment the bone marrow cells, lymphocytes, and lipoxin A4 were increased, while IL-6, IL-17, and IL-10 were decreased. No differences were observed in the blood cells and tracheal reactivity. Thus, our results showed that LED treatment attenuated ALI induced by sepsis by modulating the cell mobilization from their reserve compartments. In addition, we also showed later effects of the LED up to 7days after the treatment. This study proposes photobiomodulation as therapeutic adjuvant to treat ALI. (AU)

• Processo FAPESP: 17/06444-9 - Avaliação do tratamento com LED na resolução da lesão pulmonar aguda induzida por sepse
• Beneficiário: Adriana Lino dos Santos Franco
• Modalidade de apoio: Auxílio à Pesquisa - Regular