Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chaperone-Assisted Secretion in Bacteria: Protein and DNA Transport via Cell Membranes

Texto completo
Autor(es):
Schultz, Lilian Goulart [1] ; Tasic, Ljubica [1] ; Fattori, Juliana [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Chem, Organ Chem Dept, Chem Biol Lab, POB 6154, BR-13083970 Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo de Revisão
Fonte: CURRENT PROTEOMICS; v. 16, n. 1, p. 54-63, 2019.
Citações Web of Science: 0
Resumo

Bacteria use an impressive arsenal of secretion systems (1-7) to infect their host cells by exporting proteins, DNA and DNA-protein complexes via cell membranes. They use chaperone-usher pathways for host colonization as well. To be targeted for transportation across one (Gram-positive) or two membranes (Gram-negative), clients must be selected, guided and unfolded to pass through type 3 (T3SS) or type 4 (T4SS) secretion systems. For these processes, bacteria count on secretory chaperones that guide macromolecular transport via membranes. Moreover, if we know how these processes occur, we might be able to stop them and avoid bacterial infections. Thus, structural and functional characterizations of secretory chaperones become interesting, as these proteins are the perfect targets for blocking bacteria action. Therefore, this review focuses on a story of known mechanisms of chaperone-secretion assisted transport with special attention on virulence proteins and DNA transport in bacteria. (AU)

Processo FAPESP: 04/14584-5 - Caracterizacao estrutural de proteinas (chaperones) da bacteria xanthomonas axonopodis pv. citri.
Beneficiário:Ljubica Tasic
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/50426-6 - Resolucao estrutural de proteinas hipoteticas, chaperones de secrecao, da bacteria xanthomonas axonopodis pv. citri.
Beneficiário:Juliana Fattori
Modalidade de apoio: Bolsas no Brasil - Doutorado