A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?

Autor(es)

Sariol, Carlos A. ^{[1, 2, 3]} ; Nogueira, Mauricio L. ^[4] ; Vasilakis, Nikos ^{[5, 6, 7, 8]}

Afiliação do(s) autor(es)

^[1] Univ Puerto Rico, Caribbean Primate Res Ctr, Unit Comparat Med, Med Sci Campus, San Juan, PR 00936 - USA

^[2] Univ Puerto Rico, Dept Microbiol & Med Zool, Med Sci Campus, San Juan, PR 00936 - USA

^[3] Univ Puerto Rico, Dept Internal Med, Med Sci Campus, San Juan, PR 00936 - USA

^[4] Fac Med Sao Jose do Rio Preto, Sao Jose Do Rio Preto, SP - Brazil

^[5] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 - USA

^[6] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 - USA

^[7] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 - USA

^[8] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: TRENDS IN MICROBIOLOGY; v. 26, n. 3, p. 186-190, MAR 2018.
• Citações Web of Science: 11

Resumo

The rise of Zika virus (ZIKV) and its unusual clinical manifestations provided ground for speculative debate. The clinical severity of secondary dengue virus (DENV) infections is associated with antibody-dependent enhancement (ADE), and it was recently suggested that previous exposure to DENV may worsen ZIKV clinical outcomes. In this Opinion article we analyze the relationship among different flaviviruses and ADE. We discuss new evidence obtained in non-human primates and human cohorts demonstrating that there is no correlation to ADE when ZIKV infection occurs in the presence of pre-existing DENV immunity. We propose a redefinition of ADE in the context of complex immunological flavivirus interactions to provide a more objective perspective when translating in vitro or in vivo observations into the clinical setting. (AU)

• Processo FAPESP: 13/21719-3 - Estudo epidemiológico da dengue (sorotipos 1 a 4) em coorte prospectiva de São José do Rio Preto, São Paulo, Brasil, durante 2014 a 2018
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 16/15021-1 - Estudo clínico-epidemiológico em coorte prospectiva de gestantes infectadas pelo vírus Zika em São José do Rio Preto
• Beneficiário: Maurício Lacerda Nogueira
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa em Políticas Públicas para o SUS