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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?

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Author(s):
Sariol, Carlos A. [1, 2, 3] ; Nogueira, Mauricio L. [4] ; Vasilakis, Nikos [5, 6, 7, 8]
Total Authors: 3
Affiliation:
[1] Univ Puerto Rico, Caribbean Primate Res Ctr, Unit Comparat Med, Med Sci Campus, San Juan, PR 00936 - USA
[2] Univ Puerto Rico, Dept Microbiol & Med Zool, Med Sci Campus, San Juan, PR 00936 - USA
[3] Univ Puerto Rico, Dept Internal Med, Med Sci Campus, San Juan, PR 00936 - USA
[4] Fac Med Sao Jose do Rio Preto, Sao Jose Do Rio Preto, SP - Brazil
[5] Univ Texas Med Branch, Ctr Trop Dis, Galveston, TX 77555 - USA
[6] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 - USA
[7] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 - USA
[8] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 - USA
Total Affiliations: 8
Document type: Review article
Source: TRENDS IN MICROBIOLOGY; v. 26, n. 3, p. 186-190, MAR 2018.
Web of Science Citations: 11
Abstract

The rise of Zika virus (ZIKV) and its unusual clinical manifestations provided ground for speculative debate. The clinical severity of secondary dengue virus (DENV) infections is associated with antibody-dependent enhancement (ADE), and it was recently suggested that previous exposure to DENV may worsen ZIKV clinical outcomes. In this Opinion article we analyze the relationship among different flaviviruses and ADE. We discuss new evidence obtained in non-human primates and human cohorts demonstrating that there is no correlation to ADE when ZIKV infection occurs in the presence of pre-existing DENV immunity. We propose a redefinition of ADE in the context of complex immunological flavivirus interactions to provide a more objective perspective when translating in vitro or in vivo observations into the clinical setting. (AU)

FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
Grantee:Maurício Lacerda Nogueira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/15021-1 - Clinical-epidemiological study of a cohort of Zika infected pregnant women in São José do Rio Preto, SP
Grantee:Maurício Lacerda Nogueira
Support Opportunities: Research Grants - Research in Public Policies for the National Health Care System (PP-SUS)