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Study about Flavivirus epitopes with medical importance in Brazil and its antibodies

Grant number: 18/09383-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2018
Effective date (End): May 31, 2021
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Luiz Tadeu Moraes Figueiredo
Grantee:Marcilio Jorge Fumagalli
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/02438-6 - Studies with Bunyaviridae that produce human disease, AP.TEM

Abstract

In Brazil, there are important arboviruses capable of producing human disease, such as Dengue virus (DENV), Yellow Fever virus (YFV) and Zika Virus (ZIKV). They are transmitted by the bite of hematophagous mosquitoes, mainly of the genus Aedes, present in practically the whole Brazilian territory. The symptoms developed by DENV or ZIKV infection include abrupt fever, joint and muscle pain. In yellow fever, the symptoms may be more severe, including fulminant hepatitis, renal failure, hemorrhage and shock. Dengue fever and yellow fever may develop as high lethality haemorrhagic fevers and the Zika virus can cause severe congenital disease. Therefore, these viruses that are causing epidemics in Brazil, are of great importance for public health, requiring vigorous research and action for control. Considering the relevance of such arboviruses, we propose to study epitopes in Flavivirus proteins, mapping them with a microarray chip, a new technology. After recognition, these epitopes will be targets of studies that will include its usage in diagnosis methods of diagnosis and production of monoclonal antibodies for acute phase diagnosis, immunopathology studies, analysis of antibodies directed against the epitopes studied for viral neutralizing capacity or ADE (Antibody Dependent Enhancement). Also, epitopes will be tested as vaccine candidates and antibodies as therapeutic candidates. Eventually, the antigenic epitopes of Flaviviruses discovered or the antibodies raised against them, may become commercial products and be patented. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, WILLIAM MARCIEL; FUMAGALLI, MARCILIO JORGE; DE ARAUJO, JANSEN; OMETTO, TATIANA; MODHA, SEJAL; THOMAZELLI, LUCIANO MATSUMIYA; DURIGON, EDISON LUIS; MURCIA, PABLO RAMIRO; MORAES FIGUEIREDO, LUIZ TADEU. Discovery of novel astrovirus and calicivirus identified in ruddy turnstones in Brazil. SCIENTIFIC REPORTS, v. 9, APR 3 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.