Linear and Continuous Flavivirus Epitopes From Naturally Infected Humans

Author(s)

Fumagalli, Marcilio Jorge ^[1] ; Moraes Figueiredo, Luiz Tadeu ^[1] ; Aquino, Victor Hugo ^[2]

Affiliation

^[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Virol Res Ctr, Ribeirao Preto - Brazil

^[2] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Lab Virol, Dept Clin Anal Toxicol & Food Sci, Ribeirao Preto - Brazil

• Document type: Review article
• Source: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY; v. 11, AUG 12 2021.
• Web of Science Citations: 0

Abstract

This manuscript is an up-to-date review of experimentally validated linear and continuous epitopes identified from arbovirus members of the Flavivirus genus. We summarized 153 immunoreactive peptides from the Dengue virus, Zika virus, Japanese encephalitis virus, West Nile virus, and tick-borne encephalitis virus described in studies published from 1989 to 2020. We included peptides from structural (envelope, capsid, and pre-membrane) and nonstructural (Ns1-5) viral proteins that demonstrated relevant immunoreactivity with antibodies from naturally infected or vaccinated humans. We included peptides that demonstrated relevant reactivity features, such as indicators of disease severity related to immunological or immunopathological outcomes, differential or group diagnostic markers, immunotherapy candidates, and potential for vaccine formulation. The majority of immunoreactive peptides were described for DENV probably due to its long-lasting impact on human health and the lack of efficient vaccines and therapeutic methods. Immune landscape data regarding linear immunoreactive and continuous flavivirus peptides are still scarce, and a complete and more detailed map remains to be elucidated. Therefore, this review provides valuable data for those investigating the antibody response against flavivirus infection. (AU)

• FAPESP's process: 19/26119-0 - Emerging and re-emerging viruses: biology, pathogenesis and prospection
• Grantee: Eurico de Arruda Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/09383-3 - Study about Flavivirus epitopes with medical importance in Brazil and its antibodies
• Grantee: Marcilio Jorge Fumagalli
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/27333-6 - Pathophysiology and diagnosis of arthritogenic alphavirus infections
• Grantee: Luiz Tadeu Moraes Figueiredo
• Support Opportunities: Regular Research Grants