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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Biological response of chemically treated surface of the ultrafine-grained Ti-6Al-7Nb alloy for biomedical applications

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Autor(es):
de Oliveira, Diego Pedreira [1] ; Toniato, Tatiane Venturott [2] ; Ricci, Ritchelli [2] ; Marciano, Fernanda Roberta [3] ; Prokofiev, Egor [4] ; Valiev, Ruslan Z. [5, 4] ; Lobo, Anderson Oliveira [6] ; Jorge Junior, Alberto Moreira [1, 7, 8]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Fed Sao Carlos, Dept Mat Engn, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Vale do Paraiba, Inst Res & Dev, BR-12244000 Sao Paulo - Brazil
[3] Brasil Univ, Sci & Technol Inst, BR-08230030 Sao Paulo - Brazil
[4] St Petersburg State Univ, St Petersburg 199034 - Russia
[5] Ufa State Aviat Tech Univ, Inst Phys Adv Mat, Ufa 450000 - Russia
[6] UFPI Fed Univ Piaui, LIMAV Interdisciplinary Lab Adv Mat, Dept Mat Engn, BR-64049550 Teresina, Piaui - Brazil
[7] Univ Grenoble Alpes, CNRS, Grenoble INP, LEPMI, F-38000 Grenoble - France
[8] SIMAP Labs, F-38000 Grenoble - France
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF NANOMEDICINE; v. 14, p. 1725-1736, 2019.
Citações Web of Science: 0
Resumo

Background: Nanophase surface properties of titanium alloys must be obtained for a suitable biological performance, particularly to facilitate cell adhesion and bone tissue formation. Obtaining a bulk nanostructured material using severe plastic deformation is an ideal processing route to improve the mechanical performance of titanium alloys. By decreasing the grain size of a metallic material, a superior strength improvement can be obtained, while surface modification of a nanostructured surface can produce an attractive topography able to induce biological responses in osteoblastic cells. Methods: Aiming to achieve such an excellent synergetic performance, a processing route, which included equal channel angular pressing (ECAP), hot and cold extrusion, and heat treatments, was used to produce a nanometric and ultrafine-grained (UFG) microstructure in the Ti-6Al-7Nb alloy (around of 200 nm). Additionally, UFG samples were surface-modified with acid etching (UFG-A) to produce a uniform micron and submicron porosity on the surface. Subsequently, alkaline treatment (UFG-AA) produced a sponge-like nanotopographic substrate able to modulate cellular interactions. Results: After several kinds of biological tests for both treatment conditions (UFG-A and UFG-AA), the main results have shown that there was no cytotoxicity, expressed alkaline phosphatase activity and total protein amounts without statistical differences compared to control. However, the UFG-AA samples presented an attractive effect on the cell membranes, and cell adhesions were preferentially induced as compared with UFG-A. Both conditions demonstrated cell projections, but for UFG-AA, cells were more widely dispersed, and more quantities of filopodia formation could be observed. Conclusion: Herein, the reasons for such behaviors are discussed, and further results are presented in addition to those mentioned above. (AU)

Processo FAPESP: 13/06258-0 - Desenvolvimento de superfícies de ligas de titânio oxidadas anodicamente, modificadas com laser femtosegundo e resistentes à fadiga
Beneficiário:Diego Pedreira de Oliveira
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado