Morphological, thermal and bioactivity evaluation of electrospun PCL/beta-TCP fibers for tissue regeneration

Autor(es)

de Siqueira, Lilian ^[1] ; Passador, Fabio Roberto ^[2] ; Lobo, Anderson Oliveira ^[3] ; Triches, Eliandra de Sousa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Lab Bioceram BIOCERAM, ICT, Sao Jose Dos Campos, SP - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Lab Tecnol Polimeros & Biopolimeros TecPBio, ICT, Sao Jose Dos Campos, SP - Brazil

^[3] Univ Fed Piaui UFPI, Lab Interdisciplinar Mat Avancados LIMAV, Dept Engn Mat, Teresina, PI - Brazil

• Tipo de documento: Artigo Científico
• Fonte: POLIMEROS-CIENCIA E TECNOLOGIA; v. 29, n. 1 2019.
• Citações Web of Science: 0

Resumo

Electrospinning is a simple and low-cost way to fabricate fibers. Among the various polymers used in electrospinning, polycaprolactone (PCL) stands out due to its excellent biodegradability and biocompatibility. However, PCL has some limitations such as low bioactivity, hydrophobic surface, and long in vivo degradation. Calcium phosphate ceramics have been recognized as an attractive biomaterial. They are bioactive and osteoinductive, and some are even quite biodegradable. Different contents of particles of beta-tricalcium phosphate (beta-TCP) were incorporated in polymer matrix to form fibers of PCL/beta-TCP composites by electrospinning for possible application in tissue regeneration. The presence of beta-TCP particles promoted some changes in the thermal properties of the fibers. The immersion of PCL/beta-TCP 8 wt-% fibers in simulated body fluid (SBF) caused the formation of a denser and homogeneous apatite layer on its surface. (AU)

• Processo FAPESP: 11/17877-7 - Desenvolvimento de novos scaffolds poliméricos por eletrofiação com incorporação de nanotubos alinhados e nanohidroxiapatita para regeneração óssea
• Beneficiário: Anderson de Oliveira Lobo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 10/00863-0 - Processamento e caracterização de suportes porosos nanoestruturados do tipo B-TCP/Al2O3 para aplicações biomédicas
• Beneficiário: Eliandra de Sousa Trichês
• Modalidade de apoio: Auxílio à Pesquisa - Regular