| Texto completo | |
| Autor(es): |
Natale, Livia C.
[1]
;
Rodrigues, Marcela C.
[2]
;
Alania, Yvette
[1]
;
Chiari, Marina D. S.
[1]
;
Vilela, Handially S.
[1]
;
Vieira, Douglas N.
[1]
;
Arana-Chavez, Victor
[1]
;
Meier, Marcia M.
[3]
;
Vichi, Flavio M.
[4]
;
Braga, Roberto R.
[1]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Biomat & Oral Biol, Sao Paulo, SP - Brazil
[2] Univ Cruzeiro Sul, Sao Paulo, SP - Brazil
[3] Santa Catarina State Univ, Dept Chem, Florianopolis, SC - Brazil
[4] Univ Sao Paulo, Dept Fundamental Chem, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 107, n. 3, p. 708-715, APR 2019. |
| Citações Web of Science: | 2 |
| Resumo | |
This study describes the synthesis of dicalcium phosphate dihydrate (DCPD) particles in the presence of different ethylene glycol dimethacrylates (EGDMA, ethylene glycol/EG units: 1, 2, 3 or 4) at two monomer-to-ammonium phosphate molar ratios (1:1 and 2:1), as a strategy to develop CaP-monomer particles with improved interaction with resin matrices. Particles displaying high surface areas and organic contents were added to a photocurable BisGMA-TEGDMA resin and the resulting materials were tested for degree of conversion (DC), biaxial flexural strength (BFS), flexural modulus, and ion release. Data were subjected to one-way ANOVA or Kruskal-Wallis/Dunn test (alpha: 0.05). Functionalization with EGDMA derivatives was dependent upon the length of the spacer group and monomer concentration in the synthesis. No differences in DC were observed among materials (p>0.05). A 39% increase in BFS was obtained with the use of particles with the highest functionalization level compared to non-functionalized particles (p<0.001). The use of functionalized DCPD reduced flexural modulus in comparison to non-functionalized particles (p<0.001). Calcium release was similar among materials and remained constant during the experiment, while phosphate release was higher at 7 days in comparison to the remaining weeks (p<0.001). In conclusion, diethylene glycol dimethacrylate resulted in the highest functionalization levels and the highest BFS among DCPD-containing materials. Ion release was not affected by functionalization. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 708-715, 2019. (AU) | |
| Processo FAPESP: | 15/15019-4 - Desenvolvimento de nanopartículas de fosfato de cálcio funcionalizadas para aplicação em compósitos resinosos de uso odontológico |
| Beneficiário: | Roberto Ruggiero Braga |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |