Development of calcium phosphate/ethylene glycol dimethacrylate particles for dental applications

Autor(es)

Natale, Livia C. ^[1] ; Rodrigues, Marcela C. ^[2] ; Alania, Yvette ^[1] ; Chiari, Marina D. S. ^[1] ; Vilela, Handially S. ^[1] ; Vieira, Douglas N. ^[1] ; Arana-Chavez, Victor ^[1] ; Meier, Marcia M. ^[3] ; Vichi, Flavio M. ^[4] ; Braga, Roberto R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Biomat & Oral Biol, Sao Paulo, SP - Brazil

^[2] Univ Cruzeiro Sul, Sao Paulo, SP - Brazil

^[3] Santa Catarina State Univ, Dept Chem, Florianopolis, SC - Brazil

^[4] Univ Sao Paulo, Dept Fundamental Chem, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 107, n. 3, p. 708-715, APR 2019.
• Citações Web of Science: 2

Resumo

This study describes the synthesis of dicalcium phosphate dihydrate (DCPD) particles in the presence of different ethylene glycol dimethacrylates (EGDMA, ethylene glycol/EG units: 1, 2, 3 or 4) at two monomer-to-ammonium phosphate molar ratios (1:1 and 2:1), as a strategy to develop CaP-monomer particles with improved interaction with resin matrices. Particles displaying high surface areas and organic contents were added to a photocurable BisGMA-TEGDMA resin and the resulting materials were tested for degree of conversion (DC), biaxial flexural strength (BFS), flexural modulus, and ion release. Data were subjected to one-way ANOVA or Kruskal-Wallis/Dunn test (alpha: 0.05). Functionalization with EGDMA derivatives was dependent upon the length of the spacer group and monomer concentration in the synthesis. No differences in DC were observed among materials (p>0.05). A 39% increase in BFS was obtained with the use of particles with the highest functionalization level compared to non-functionalized particles (p<0.001). The use of functionalized DCPD reduced flexural modulus in comparison to non-functionalized particles (p<0.001). Calcium release was similar among materials and remained constant during the experiment, while phosphate release was higher at 7 days in comparison to the remaining weeks (p<0.001). In conclusion, diethylene glycol dimethacrylate resulted in the highest functionalization levels and the highest BFS among DCPD-containing materials. Ion release was not affected by functionalization. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 708-715, 2019. (AU)

• Processo FAPESP: 15/15019-4 - Desenvolvimento de nanopartículas de fosfato de cálcio funcionalizadas para aplicação em compósitos resinosos de uso odontológico
• Beneficiário: Roberto Ruggiero Braga
• Modalidade de apoio: Auxílio à Pesquisa - Regular