Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status

Autor(es)

Borges Botelho, Ilka Mara ^[1] ; Neto, Arnaldo Moura ^[1] ; Silva, Conceicao Aparecida ^[2] ; Tambascia, Marcos Antonio ^[1] ; Alegre, Sarah Monte ^[3] ; Zantut-Wittmann, Dcnisc Engelbrecht ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Endocrinol Div, 126 Tessalia Vieira Camargo St, BR-13083887 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Biol Inst, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Metabol Unit, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ENDOCRINE JOURNAL; v. 65, n. 10, p. 1029-1037, 2018.
• Citações Web of Science: 1

Resumo

Several studies have shown the correlation between vitamin D {[}25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytokines produced by Th1, Th2, and Th17 cells compared with a control group of 71 euthyroid healthy subjects. The present study demonstrated that vitamin D concentrations were similar in patients HT and the control group. The reduction of free T4 levels was a predictor of vitamin D insufficiency for Hashimoto's thyroiditis, but not for the control group. Lower concentrations of TNF-alpha was a predictor of lower levels of vitamin D. Differences in the association between TIT and vitamin D insufficiency remain unresolved in the literature. The thyroid honnone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels. (AU)

• Processo FAPESP: 12/20984-2 - Tireoidite de Hashimoto e deficiência de Vitamina D: estudo de prevalência e relação com autoimunidade
• Beneficiário: Denise Engelbrecht Zantut Wittmann
• Modalidade de apoio: Auxílio à Pesquisa - Regular