| Full text | |
| Author(s): |
Borges Botelho, Ilka Mara
[1]
;
Neto, Arnaldo Moura
[1]
;
Silva, Conceicao Aparecida
[2]
;
Tambascia, Marcos Antonio
[1]
;
Alegre, Sarah Monte
[3]
;
Zantut-Wittmann, Dcnisc Engelbrecht
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Endocrinol Div, 126 Tessalia Vieira Camargo St, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Biol Inst, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Metabol Unit, Campinas, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | ENDOCRINE JOURNAL; v. 65, n. 10, p. 1029-1037, 2018. |
| Web of Science Citations: | 1 |
| Abstract | |
Several studies have shown the correlation between vitamin D {[}25(OH)D] deficiency and thyroid autoimmunity and reducing of thyroid autoantibodies in patients with normal levels of vitamin D combining with thyroid hormone replacement. However, other authors not agree with this association. It is still unclear whether the low 25(OH)D levels are the result of HT disease or a part of its cause. We studied 88 patients with HT regarding vitamin D status and thyroid autoimmunity markers as well as the relationship with cytokines produced by Th1, Th2, and Th17 cells compared with a control group of 71 euthyroid healthy subjects. The present study demonstrated that vitamin D concentrations were similar in patients HT and the control group. The reduction of free T4 levels was a predictor of vitamin D insufficiency for Hashimoto's thyroiditis, but not for the control group. Lower concentrations of TNF-alpha was a predictor of lower levels of vitamin D. Differences in the association between TIT and vitamin D insufficiency remain unresolved in the literature. The thyroid honnone status would play a role in the maintenance of vitamin D sufficiency, and its immunomodulatory role would influence the presence of autoimmune thyroid disease. The positive correlation between free T4 and vitamin D concentrations suggests that adequate levothyroxine replacement in HT would be an essential factor in maintaining vitamin D at sufficient levels. (AU) | |
| FAPESP's process: | 12/20984-2 - Hashimoto's thyroiditis and Vitamin D deficiency: study of prevalence and relationship with autoimmunity |
| Grantee: | Denise Engelbrecht Zantut Wittmann |
| Support Opportunities: | Regular Research Grants |