Treatment of Intrabony Defects with Anorganic Bone Matrix/P-15 or Guided Tissue Regeneration in Patients with Aggressive Periodontitis

Autor(es)

Adriana C. Queiroz ^[1] ; Priscila Brasil da Nobrega ^[2] ; Fabiola S. Oliveira ^[3] ; Arthur B. Novaes Jr. ^[4] ; Mario Taba Jr. ^[5] ; Daniela B. Palioto ^[6] ; Marcio F. M. Grisi ^[7] ; Sergio L. S. Souza ^[8]

Afiliação do(s) autor(es)

^[1] UFAM - Federal University of Amazonas. Dental School - Brasil

^[2] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

^[3] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

^[4] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

^[5] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

^[6] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

^[7] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

^[8] USP - University of Sao Paulo. Dental School of Ribeirao Preto. Oral and Maxillofacial Traumatology and Periodontology - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 24, n. 3, p. 204-212, 2013-06-00.

Resumo

Intrabony periodontal defects present a particular treatment problem, especially in patients with generalized aggressive periodontitis (G-AgP). Regenerative procedures have been indicated for this clinical situation. The aim of this study was to compare treatment outcomes of intrabony periodontal defects with either anorganic bone matrix/cell binding peptide (ABM/P-15) or guided tissue regeneration (GTR) in patients with G-AgP. Fifteen patients, with two intrabony defects ≥3 mm deep, were selected. Patients were randomly allocated to be treated with ABM/P-15 or GTR. At baseline and at 3 and 6 months after surgery, clinical and radiographic parameters and IL-1β and IL-6 gingival fluid concentrations were recorded. There was a significant probing pocket depth reduction (p<0.001) for both groups (2.27 ± 0.96 mm for ABM/P-15 group and 2.57 ± 1.06 mm for GTR group). Clinical attachment level gain (1.87 ± 0.94 mm for ABM/P-15 group and 2.09 ± 0.88 mm for GTR group) was also observed. There were no statistically significant differences in clinical parameters between the groups. The radiographic bone fill was more expressive in ABM/P-15 group (2.49 mm) than in GTR group (0.73 mm). In subtraction radiographs, the areas representing gain in density were 93.16% of the baseline defect for ABM/P-15 group versus 62.03% in GRT group. There were no statistically significant differences in inter-group and intra-group comparisons with regards to IL-1β and IL-6 quantification. Treatment of intrabony periodontal defects in patients with G-AgP with ABM/P-15 and GTR improved significantly the clinical outcomes. The use of ABM/P-15 promoted a better radiographic bone fill. (AU)

• Processo FAPESP: 06/04404-5 - Avaliacao do uso de pepgen p-15 no tratamento de defeitos intra-osseos em pacientes com periodondite agressiva.estudo clinico, radiografico e laboratorial em humanos.
• Beneficiário: Sérgio Luís Scombatti de Souza
• Modalidade de apoio: Auxílio à Pesquisa - Regular