Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection

Autor(es)

Maria Gabriela Haye Biazevic ^[1] ; José Leopoldo Ferreira Antunes ^[2] ; Janina Togni ^[3] ; Fabiana Paula de Andrade ^[4] ; Marcos Brasilino de Carvalho ^[5] ; Victor Wünsch-Filho ^[6]

Afiliação do(s) autor(es)

^[1] University of São Paulo. School of Dentistry - Brasil

^[2] University of São Paulo. Science and Humanity. School of Arts - Brasil

^[3] University of São Paulo. School of Dentistry - Brasil

^[4] University of São Paulo. School of Dentistry - Brasil

^[5] Heliópolis Hospital. Head and Neck Surgery Service - Brasil

^[6] University of São Paulo. School of Public Health - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Applied Oral Science; v. 18, n. 3, p. 279-284, 2010-06-00.

Resumo

OBJECTIVE: This study aimed to assess the survival and life quality evolution of patients subjected to surgical excision of oral and oropharyngeal squamous cell carcinoma. MATERIAL AND METHODS: Forty-seven patients treated at a Brazilian healthcare unit specialized in head and neck surgery between 2006 and 2007 were enrolled in the study. The gathering of data comprised reviewing hospital files and applying the University of Washington Quality of Life (UW-QOL) questionnaire previously and 1 year after the surgery. Comparative analysis used Poisson regression to assess factors associated with survival and a paired t-test to compare preoperative and 1-year postoperative QOL ratings. RESULTS: 1 year after surgery, 7 patients were not found (dropout of the cohort); 15 had died and 25 fulfilled the UW-QOL again. The risk of death was associated with having regional metastasis previously to surgery (relative risk=2.18; 95% confidence interval=1.09-5.17) and tumor size T3 or T4 (RR=2.30; 95%CI=1.05-5.04). Survivors presented significantly (p<0.05) poorer overall and domain-specific ratings of quality of life. Chewing presented the largest reduction: from 74.0 before surgery to 34.0 one year later. Anxiety was the only domain whose average rating increased (from 36.0 to 70.7). CONCLUSIONS: The prospective assessment of survival and quality of life may contribute to anticipate interventions aimed at reducing the incidence of functional limitations in patients with oral and oropharyngeal cancer. (AU)

• Processo FAPESP: 06/01238-7 - Qualidade de vida de pacientes com câncer de boca e orofaringe do Projeto Genoma Clínico
• Beneficiário: Maria Gabriela Haye Biazevic
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado