Change in the antimicrobial resistance profile of Pseudomonas aeruginosa from soil after exposure to herbicides

Autor(es)

Braz, Vania Santos ^[1] ; Silva Moretto, Jessica Aparecida ^[1] ; Tonelli Fernandes, Ana Flavia ^[1] ; Stehling, Eliana Guedes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo USP Ribeirao Preto, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMIN; v. 54, n. 4, p. 290-293, APR 3 2019.
• Citações Web of Science: 0

Resumo

The extensive use of pesticides represents a risk to human health and to the environment. This study aimed to investigate if the exposure to atrazine and diuron, two herbicides widely used in Brazil, could induce changes in the susceptibility profile to aztreonam, colistin and polymyxin B antimicrobials in isolates of P. aeruginosa obtained from soil samples by using the determination of minimum inhibitory concentration (MIC) test. Three isolates had an increase of MIC to aztreonam after exposure to both herbicides and one isolate did not show any MIC change. The MexAB-OprM efflux pump has already been upregulated in these isolates and the herbicides atrazine and diuron did not increase MexAB-OprM overexpression. Therefore, the decrease in aztreonam susceptibility was not directly related to this pump, suggesting that probably other mechanisms should be involved. (AU)

• Processo FAPESP: 14/02806-5 - Desenvolvimento de consórcios bacterianos para biodegradação da atrazina
• Beneficiário: Ana Flavia Tonelli Scaranello
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/18990-2 - Investigação dos mecanismos de resistência às quinolonas em isolados bacterianos ambientais
• Beneficiário: Eliana Guedes Stehling
• Modalidade de apoio: Auxílio à Pesquisa - Regular