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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Direct Measurements of Abdominal Visceral Fat and Cognitive Impairment in Late Life: Findings From an Autopsy Study

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Autor(es):
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Nishizawa, Aline [1] ; Cuelho, Anderson [2] ; de Farias-Itao, Daniela S. [3] ; Campos, Fernanda M. [1] ; Leite, Renata E. P. [4] ; Ferretti-Rebustini, Renata E. L. [5] ; Grinberg, Lea T. [6] ; Nitrini, Ricardo [7] ; Jacob-Filho, Wilson [4] ; Pasqualucci, Carlos A. [1] ; Suemoto, Claudia K. [4]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo - Brazil
[2] Fed Univ ABC, Dept Biomed, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Expt Pathophysiol Program, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Div Geriatr, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, Sao Paulo - Brazil
[6] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA - USA
[7] Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo - Brazil
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN AGING NEUROSCIENCE; v. 11, MAY 7 2019.
Citações Web of Science: 0
Resumo

Background: The relationship between cognitive impairment and abdominal visceral is controversial. Moreover, all studies so far used imaging studies to evaluate visceral fat and this association has not been described yet using autopsy material, which allows the direct quantification of abdominal fat. We aimed to investigate the association between direct measurements of abdominal visceral fat and cognitive impairment in an autopsy study. Methods: In this cross-sectional study, we collected information on sociodemographics, cardiovascular risk factors, and cognitive status from subjects aged 50 or older at time of death in a general autopsy service in Brazil. Abdominal visceral fat was obtained in natura by the dissection of perirenal, mesenteric, omental, and mesocolon fat. The associations of total abdominal visceral fat with cognitive impairment {[}clinical dementia rating (CDR) score >= 0.5] and CDR-sum of boxes (CDR-SB) were evaluated using logistic regression and negative binomial regression models, respectively. All analyses were adjusted for height, age, sex, education, hypertension, diabetes mellitus, stroke, smoking, alcohol use, and physical inactivity. In addition, we compared the discrimination of visceral fat, body mass index (BMI), and waist circumference (WC) measurements in predicting cognitive impairment. Results: We evaluated 234 participants (mean age = 71.2 +/- 12.9 years old, 59% male). Abdominal visceral fat was inversely associated with cognitive impairment (OR = 0.46, CI = 0.30; 0.70, p < 0.0001) and with CDR-SB scores (beta = 0.85, 95% CI = 1.28; 0.43, p < 0.0001). When we compared the area under the ROC curve (AUC), visceral fat (AUC = 0.754), BMI (AUC = 0.729), and WC (AUC = 0.720) showed similar discrimination in predicting cognitive impairment (p = 0.38). Conclusion: In an autopsy study, larger amount of directly measured abdominal visceral fat was associated with lower odds of cognitive impairment in older adults. (AU)

Processo FAPESP: 12/25337-5 - Associação entre gordura visceral abdominal e demência
Beneficiário:Anderson Cuelho
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/12290-3 - Associação entre inflamação no tecido adiposo epicárdico e doença arterial coronariana: um estudo clinicopatológico
Beneficiário:Daniela Souza Farias Itao
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 17/11313-0 - Caracterização do perfil da resposta inflamatória no tecido adiposo perivascular associada à doença arterial coronariana: um estudo de autópsia
Beneficiário:Claudia Kimie Suemoto
Linha de fomento: Auxílio à Pesquisa - Regular