Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of photobiomodulation therapy on inflammatory mediators in patients with chronic non-specific low back pain Protocol for a randomized placebo-controlled trial

Texto completo
Autor(es):
Tomazoni, Shaiane Silva [1, 2] ; Pena Costa, Leonardo Oliveira [1] ; Joensen, Jon [2] ; Stausholm, Martin Bjorn [2] ; Naterstad, Ingvill Fjell [2] ; Pinto Leal-Junior, Ernesto Cesar [3, 4] ; Bjordal, Jan Magnus [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Cidade Sao Paulo, Masters & Doctoral Programs Phys Therapy, Sao Paulo - Brazil
[2] Univ Bergen, Dept Global Publ Hlth & Primary Care, Physiotherapy Res Grp, Bergen - Norway
[3] Nove Julho Univ, Postgrad Program Rehabil Sci, Sao Paulo - Brazil
[4] Nove Julho Univ, Lab Phototherapy & Innovat Technol Hlth, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: MEDICINE; v. 98, n. 15 APR 2019.
Citações Web of Science: 1
Resumo

Introduction: Low back pain (LBP) is ranked as one of the most prevalent health conditions. It is likely that some inflammatory mediators could be associated with pain and disability in these patients. Photobiomodulation therapy (PBMT) is a non-pharmacological therapy often used in patients with LBP and one of the possible mechanisms of action of therapy is modulate inflammatory mediators. However, to date there are no studies that evaluated the effects of PBMT on the levels of inflammatory mediators in patients with LBP. The aim of this study is to evaluate the acute effects of PBMT on systemic levels of inflammatory mediators and pain intensity in patients with chronic non-specific low back pain. Methods and analysis: This is a prospectively registered, two-arm randomized placebo-controlled trial with blinded patients, assessors and therapists. Eighteen patients with chronic non-specific LBP will be randomized into 2 groups: placebo or active PBMT. The treatment will be provided in a single session. The primary outcome will be levels of prostaglandin E-2 (PGE(2)). The secondary outcomes will be levels of necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6) and pain intensity. Biochemical and clinical outcomes will be measured at baseline and 15 minutes after the single treatment session. Discussion: Despite PBMT be used in musculoskeletal disorders such as LBP, to the best of our knowledge this is the first study that will investigate a possible biological mechanism behind the positive clinical effects of PBMT on non-specific chronic low back pain. Ethics and dissemination: The study was approved by the Regional Research Ethics Committee. The results will be disseminated through publication in peer-reviewed international journal and conferences. Trial registration number: NCT03859505. (AU)

Processo FAPESP: 17/18863-6 - Efeitos da terapia com fotobiomodulação sobre marcadores inflamatórios em pacientes com dor lombar crônica não específica: um estudo placebo controlado aleatorizado
Beneficiário:Shaiane da Silva Tomazoni
Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado