Models for Similarity Distributions of Syntenic Homologs and Applications to Phylogenomics

Autor(es)

Sankoff, David ^[1] ; Zheng, Chunfang ^[1] ; Zhang, Yue ^[1] ; Meidanis, Joao ^[1] ; Lyons, Eric ^[2] ; Tang, Haibao ^[2]

Afiliação do(s) autor(es)

^[1] Univ Ottawa, Dept Math & Stat, Ottawa, ON K1N 6N5 - Canada

^[2] Univ Arizona, Sch Plant Sci, Tucson, AZ 85721 - USA

• Tipo de documento: Artigo Científico
• Fonte: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS; v. 16, n. 3, p. 727-737, MAY-JUN 2019.
• Citações Web of Science: 4

Resumo

We outline an integrated approach to speciation and whole genome doubling (WGD) to resolve the occurrence of these events in phylogenetic analysis. We propose a more principled way of estimating the parameters of gene divergence and fractionation than the standard mixture of normals analysis. We formulate an algorithm for resolving data on local peaks in the distributions of duplicate gene similarities for a number of related genomes. We illustrate with a comprehensive analysis of WGD-origin duplicate gene data from the family Brassicaceae. (AU)

• Processo FAPESP: 16/01511-7 - Algoritmos para genômica comparativa de culturas e outras plantas com flores
• Beneficiário: João Meidanis
• Modalidade de apoio: Bolsas no Exterior - Pesquisa