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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Models for Similarity Distributions of Syntenic Homologs and Applications to Phylogenomics

Full text
Author(s):
Sankoff, David [1] ; Zheng, Chunfang [1] ; Zhang, Yue [1] ; Meidanis, Joao [1] ; Lyons, Eric [2] ; Tang, Haibao [2]
Total Authors: 6
Affiliation:
[1] Univ Ottawa, Dept Math & Stat, Ottawa, ON K1N 6N5 - Canada
[2] Univ Arizona, Sch Plant Sci, Tucson, AZ 85721 - USA
Total Affiliations: 2
Document type: Journal article
Source: IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS; v. 16, n. 3, p. 727-737, MAY-JUN 2019.
Web of Science Citations: 4
Abstract

We outline an integrated approach to speciation and whole genome doubling (WGD) to resolve the occurrence of these events in phylogenetic analysis. We propose a more principled way of estimating the parameters of gene divergence and fractionation than the standard mixture of normals analysis. We formulate an algorithm for resolving data on local peaks in the distributions of duplicate gene similarities for a number of related genomes. We illustrate with a comprehensive analysis of WGD-origin duplicate gene data from the family Brassicaceae. (AU)

FAPESP's process: 16/01511-7 - Algorithms for comparative genomics of crops and other flowering plants
Grantee:João Meidanis
Support Opportunities: Scholarships abroad - Research