Heritability of semantic verbal fluency task using time-interval analysis

Autor(es):Mostrar menos -

Taporoski, T. P. ^{[1, 2, 3]} ; Duarte, N. E. ^{[1, 4]} ; Pompeia, S. ^[5] ; Sterr, A. ^[6] ; Gomez, L. M. ^[1] ; Alvim, R. O. ^{[7, 1]} ; Horimoto, R. V. R. ^[1] ; Krieger, J. E. ^[1] ; Vallada, H. ^[2] ; Pereira, A. C. ^[1] ; von Schantz, M. ^{[2, 3]} ; Negrao, A. B. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Heart Inst, Lab Genet & Mol Cardiol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, FMUSP, Fac Med, Inst Psychiat LIM 23, Sao Paulo, SP - Brazil

^[3] Univ Surrey, Fac Hlth & Med Sci, Dept Biochem Sci, Guildford, Surrey - England

^[4] Univ Nacl Colombia, Dept Matemat, Manizales - Colombia

^[5] Univ Fed Sao Paulo, Escola Paulista Med, Dept Psychobiol, Sao Paulo, SP - Brazil

^[6] Univ Surrey, Dept Psychol Sci, Guildford, Surrey - England

^[7] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 14, n. 6 JUN 11 2019.
• Citações Web of Science: 0

Resumo

Individual variability in word generation is a product of genetic and environmental influences. The genetic effects on semantic verbal fluency were estimated in 1,735 participants from the Brazilian Baependi Heart Study. The numbers of exemplars produced in 60 s were broken down into time quartiles because of the involvement of different cognitive processes-predominantly automatic at the beginning, controlled/executive at the end. Heritability in the unadjusted model for the 60-s measure was 0.32. The best-fit model contained age, sex, years of schooling, and time of day as covariates, giving a heritability of 0.21. Schooling had the highest moderating effect. The highest heritability (0.17) was observed in the first quartile, decreasing to 0.09, 0.12, and 0.0003 in the following ones. Heritability for average production starting point (intercept) was 0.18, indicating genetic influences for automatic cognitive processes. Production decay (slope), indicative of controlled processes, was not significant. The genetic influence on different quartiles of the semantic verbal fluency test could potentially be exploited in clinical practice and genome-wide association studies. (AU)

• Processo FAPESP: 13/17368-0 - Genômica cardiovascular: mechanismos & novas terapias - CVGen mech2ther
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático