Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging

Autor(es):Mostrar menos -

Soares, Guilherme A. ^[1] ; Prospero, Andre G. ^[1] ; Calabresi, Marcos F. ^[1] ; Rodrigues, Diego S. ^[2] ; Simoes, Luis G. ^[1] ; Quini, Caio C. ^[1] ; Matos, Ronaldo R. ^[1] ; Pinto, Leonardo A. ^[1] ; Sousa-Junior, Ailton A. ^[3] ; Bakuzis, Andris F. ^[3] ; Mancera, Paulo A. ^[4] ; Miranda, Jose R. A. ^[1]

Afiliação do(s) autor(es)

^[1] UNESP Sao Paulo State Univ, Lab Biomagnetismo, Dept Fis & Biofis, BR-18618689 Botucatu, SP - Brazil

^[2] UNIFAL MG Univ Fed Alfenas MG, Dept Fis, ICEx, BR-37133840 Alfenas, MG - Brazil

^[3] Univ Fed Goias, Inst Fis, BR-74690900 Goiania, Go - Brazil

^[4] UNESP Sao Paulo State Univ, Dept Bioestat, IBB, BR-18618689 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: IEEE Transactions on Nanobioscience; v. 18, n. 3, p. 456-462, JUL 2019.
• Citações Web of Science: 0

Resumo

In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP. (AU)

• Processo FAPESP: 15/14923-9 - Instrumentação e aplicações por biosusceptometria de corrente alternada: estudos de distribuição de nanopartículas, motilidade e controle da qualidade de formas farmacêuticas sólidas
• Beneficiário: José Ricardo de Arruda Miranda
• Linha de fomento: Auxílio à Pesquisa - Regular