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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging

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Autor(es):
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Soares, Guilherme A. [1] ; Prospero, Andre G. [1] ; Calabresi, Marcos F. [1] ; Rodrigues, Diego S. [2] ; Simoes, Luis G. [1] ; Quini, Caio C. [1] ; Matos, Ronaldo R. [1] ; Pinto, Leonardo A. [1] ; Sousa-Junior, Ailton A. [3] ; Bakuzis, Andris F. [3] ; Mancera, Paulo A. [4] ; Miranda, Jose R. A. [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] UNESP Sao Paulo State Univ, Lab Biomagnetismo, Dept Fis & Biofis, BR-18618689 Botucatu, SP - Brazil
[2] UNIFAL MG Univ Fed Alfenas MG, Dept Fis, ICEx, BR-37133840 Alfenas, MG - Brazil
[3] Univ Fed Goias, Inst Fis, BR-74690900 Goiania, Go - Brazil
[4] UNESP Sao Paulo State Univ, Dept Bioestat, IBB, BR-18618689 Botucatu, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: IEEE Transactions on Nanobioscience; v. 18, n. 3, p. 456-462, JUL 2019.
Citações Web of Science: 0
Resumo

In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP. (AU)

Processo FAPESP: 15/14923-9 - Instrumentação e aplicações por biosusceptometria de corrente alternada: estudos de distribuição de nanopartículas, motilidade e controle da qualidade de formas farmacêuticas sólidas
Beneficiário:José Ricardo de Arruda Miranda
Linha de fomento: Auxílio à Pesquisa - Regular