| Texto completo | |
| Autor(es): |
da Silva Miyaguti, Natalia Angelo
[1]
;
Pereira de Oliveira, Sarah Christine
[1]
;
Cintra Gomes-Marcondes, Maria Cristina
[1]
Número total de Autores: 3
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, UNICAMP, Dept Struct & Funct Biol, Lab Nutr & Canc, Biol Inst, Rua Monteiro Lobato 255, BR-13083862 Campinas, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMOLECULES; v. 9, n. 6 JUN 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved muscle protein turnover by modifying the mTOR and proteolytic pathways, thus we analysed whether maternal supplementation could ameliorate muscle protein turnover in adult offspring tumour-bearing rats. Pregnant Wistar rats received a control diet or 3% leucine-rich diet during pregnancy/lactation, and their weaned male offspring received a control diet until adulthood when they were distributed into following groups (n = 7-8 per group): C, Control; W, tumour-bearing; L, without tumour with a maternal leucine-rich diet; and WL, tumour-bearing with a maternal leucine-rich diet. Protein synthesis and degradation were assessed in the gastrocnemius muscle, focusing on the mTOR pathway, which was extensively altered in W group. However, the WL adult offspring showed no decrease in muscle weight, higher food intake, ameliorated muscle turnover, activated mTOR and p70S6K, and maintained muscle cathepsin H and calpain activities. Maternal leucine nutritional supplementation could be a positive strategy to improve muscle protein balance in cancer cachexia-induced muscle damage in adult offspring rats. (AU) | |
| Processo FAPESP: | 17/10809-2 - Avaliação do perfil de Metilação do DNA nos tecidos muscular e tumoral em ratos adultos, portadores do carcinossarcoma de Walker 256, provenientes da prole de ratas submetidas à dieta com óleo de fígado de bacalhau |
| Beneficiário: | Sarah Christine Pereira de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 17/02739-4 - Nutrição e câncer: estudo dos aspectos moleculares, proteômicos e metabolômicos em modelo experimental de caquexia |
| Beneficiário: | Maria Cristina Cintra Gomes Marcondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/13334-7 - Nutrição e câncer: avaliação do perfil metabolômico, proteômico e das vias de sinalização celular muscular, placentária e fetal e do tecido tumoral sob influência dos hormônios da gravidez em ratas |
| Beneficiário: | Maria Cristina Cintra Gomes Marcondes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |