Optimized-Surface Wettability: A New Experimental 3D Modeling Approach Predicting Favorable Biomaterial-Cell Interactions

Autor(es)

do Nascimento, Rodney Marcelo ^{[1, 2, 3]} ; Sarig, Udi ^{[4, 5]} ; do Cruz, Nilson Cristino ^[6] ; de Carvalho, Vanessa Rafaela ^[7] ; Eyssartier, Camille ^[8] ; Siad, Larbi ^[9] ; Ganghoffer, Jean-Francois ^[3] ; Hernandes, Antonio Carlos ^[1] ; Rahouadj, Rachid ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil

^[2] Univ Fed Santa Catarina, Dept Fis, Campus Reitor Joao David Ferreira Lima S-N, BR-88040900 Florianopolis, SC - Brazil

^[3] Univ Lorraine, UMR CNRS 7239, LEM3, F-57070 Nancy - France

^[4] Technion Israel Inst Technol, Biotechnol & Food Engn, IL-32000 Haifa - Israel

^[5] Guangdong Technion Israel Inst Technol, Biotechnol & Food Engn, Shantou 515063, Guangdong - Peoples R China

^[6] Sao Paulo State Univ, Lab Technol Plasmas, Sorocaba - Brazil

^[7] Sao Paulo State Univ, Sch Agr, Multiuser Cent Lab, BR-18087180 Botucatu, SP - Brazil

^[8] Ecole Natl Super Mines, Campus Artem CS 14 234, 92, Nancy - France

^[9] Univ Reims, Biomat & Inflammat Site Osseux, BIOS, EA CNRS 4691, F-51095 Reims - France

• Tipo de documento: Artigo Científico
• Fonte: ADVANCED THEORY AND SIMULATIONS; v. 2, n. 7 JUL 2019.
• Citações Web of Science: 0

Resumo

Despite several decades of research on biomedical implant materials, the identification of predictive and robust in vitro characteristics of cell support ability and viabilities as indicators of biocompatibility and future implant-tissue integration-remain elusive. This study addresses the phenomenology of cell-implant interfaces based on experimental, theoretical, and numerical analysis of cell response to functionalized bioceramic coatings of commercial titanium implants, cp-Ti. A variable spectrum of coatings having differing surface wettabilities, with optimized solid tension values, is obtained. Measured values are modeled and correlated to cell support ability and viabilities. The contributions of different surface aspects to cell viability are decoupled, resulting in the identification of the polar component of the surface free energy as a significant and major cell-substrate effector. Furthermore, results of this study and the suggested model establish the thermodynamic interfacial free energy as an omnipotent measure that can be fully correlated to the morphology of an individual cell under numerical simulation matching empirical observations. Collectively, the 3D model reported herein can offer a new generic theoretical framework, using implementable mathematical simulation, toward the objective of rational biomaterial design that can improve next-generation metal and ceramic implants. (AU)

• Processo FAPESP: 17/03842-3 - Estudo da Regeneração Tecidual Guiada (GTR) através de análise experimental em disco articular temporo-mandibular e membranas oclusivas NR-CaP
• Beneficiário: Rodney Marcelo do Nascimento
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 13/21970-8 - Desenvolvimento de biomaterial a partir da incorporação de fosfatos de cálcio em estruturas de látex visando aplicação como dispositivo de liberação controlada
• Beneficiário: Rodney Marcelo do Nascimento
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado