| Texto completo | |
| Autor(es): Mostrar menos - |
Gleeson, Padraig
[1]
;
Cantarelli, Matteo
[2, 1]
;
Marin, Boris
[3, 1]
;
Quintana, Adrian
[1]
;
Earnshaw, Matt
[1]
;
Sadeh, Sadra
[1]
;
Piasini, Eugenio
[4, 1, 5]
;
Birgiolas, Justas
[6]
;
Cannon, Robert C.
[7]
;
Cayco-Gajic, N. Alex
[1]
;
Crook, Sharon
[6, 8]
;
Davison, Andrew P.
[9]
;
Dura-Bernal, Salvador
[10, 11]
;
Ecker, Andras
[1, 12]
;
Hines, Michael L.
[13]
;
Idili, Giovanni
[2]
;
Lanore, Frederic
[1]
;
Larson, Stephen D.
[14]
;
Lytton, William W.
[10, 11]
;
Majumdar, Amitava
[15]
;
McDougal, Robert A.
[13, 16]
;
Sivagnanam, Subhashini
[15]
;
Solinas, Sergio
[17, 18, 19]
;
Stanislovas, Rokas
[1]
;
van Albada, Sacha J.
[20, 21]
;
van Geit, Werner
[12]
;
Silver, R. Angus
[1]
Número total de Autores: 27
|
| Afiliação do(s) autor(es): Mostrar menos - | [1] UCL, Dept Neurosci Physiol & Pharmacol, London - England
[2] MetaCell Ltd, Oxford - England
[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Santo Andre - Brazil
[4] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 - USA
[5] Univ Penn, Computat Neurosci Initiat, Philadelphia, PA 19104 - USA
[6] Arizona State Univ, Sch Life Sci, Tempe, AZ - USA
[7] Annotate Software Ltd, Edinburgh, Midlothian - Scotland
[8] Arizona State Univ, Sch Math & Stat Sci, Tempe, AZ - USA
[9] CNRS, Unite Neurosci Informat & Complexite, Paris - France
[10] Suny Downstate Med Ctr, Brooklyn, NY 11203 - USA
[11] Kings Cty Hosp, Brooklyn, NY - USA
[12] Ecole Polytech Fed Lausanne, Blue Brain Project, Lausanne - Switzerland
[13] Yale Sch Med, Dept Neurosci, New Haven, CT - USA
[14] OpenWorm Fdn, Boston, MA - USA
[15] Univ Calif San Diego, San Diego, CA 92103 - USA
[16] Yale Univ, Ctr Med Informat, New Haven, CT - USA
[17] Univ Sassari, Dept Biomed Sci, Sassari - Italy
[18] Univ Zurich, Inst Neuroinformat, Zurich - Switzerland
[19] Swiss Fed Inst Technol, Zurich - Switzerland
[20] Julich Res Ctr, Inst Neurosci & Med INM 6, Inst Adv Simulat IAS 6, Julich - Germany
[21] Julich Res Ctr, JARA Inst Brain Struct Funct Relationships INM 10, Julich - Germany
Número total de Afiliações: 21
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NEURON; v. 103, n. 3, p. 395+, AUG 7 2019. |
| Citações Web of Science: | 1 |
| Resumo | |
Computational models are powerful tools for exploring the properties of complex biological systems. In neuroscience, data-driven models of neural circuits that span multiple scales are increasingly being used to understand brain function in health and disease. But their adoption and reuse has been limited by the specialist knowledge required to evaluate and use them. To address this, we have developed Open Source Brain, a platform for sharing, viewing, analyzing, and simulating standardized models from different brain regions and species. Model structure and parameters can be automatically visualized and their dynamical properties explored through browser-based simulations. Infrastructure and tools for collaborative interaction, development, and testing are also provided. We demonstrate how existing components can be reused by constructing new models of inhibition-stabilized cortical networks that match recent experimental results. These features of Open Source Brain improve the accessibility, transparency, and repro-ducibility of models and facilitate their reuse by the wider community. (AU) | |
| Processo FAPESP: | 17/04748-0 - Ferramentas de neuroinformática para modelagem declarativa multiescala via geração automática de implementações, com aplicações a modelagem de grande escala da retina de vertebrados |
| Beneficiário: | Bóris Marin |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |