Assessment of Cardiotoxicity of Cancer Chemotherapy The Value of Cardiac MR Imaging

Autor(es)

de Souza, Thiago Ferreira ^[1] ; Quinaglia, Thiago ^[1] ; Neilan, Tomas G. ^{[2, 3]} ; Coelho-Filho, Otavio R. ^{[1, 4]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Ciencias Med, Rua Tessalia Vieira de Camargo 126, BR-13083887 Campinas, SP - Brazil

^[2] Harvard Med Sch, Massachusetts Gen Hosp, Cardiooncol Program, 55 Fruit St, Boston, MA 02114 - USA

^[3] Harvard Med Sch, Massachusetts Gen Hosp, Cardiac MR PET CT Program, 55 Fruit St, Boston, MA 02114 - USA

^[4] State Univ Campinas UNICAMP, Dept Med, Div Cardiol, Rua Tessalia Vieira de Camargo 126, BR-13083887 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA; v. 27, n. 3, p. 533+, AUG 2019.
• Citações Web of Science: 0

Resumo

Chemotherapy is associated with cardiovascular injury, including the development of a cardiomyopathy and vascular remodeling. Cardiac magnetic resonance (CMR) is sensitive to detect not only established morphologic and functional abnormalities but also early, potentially reversible, signs of myocardial injury. It robustly detects and quantifies myocardial edema, inflammation, and focal fibrosis, as well as interstitial fibrosis and vascular remodeling. These capabilities support the role of CMR as an excellent tool for evaluating cardiotoxicity. Novel CMR markers may even enhance patient management by facilitating the early detection of reversible myocardial tissue remodeling before classic morphologic and functional changes appear. (AU)

• Processo FAPESP: 15/15402-2 - Caracterização da fibrose intersticial e da hipertrofia dos cardiomiócitos pela ressonância magnética cardíaca: implicações no remodelamento precoce e na transição para insuficiência cardíaca
• Beneficiário: Otávio Rizzi Coelho-Filho
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores