Assessment of Cardiotoxicity of Cancer Chemotherapy The Value of Cardiac MR Imaging

Author(s)

de Souza, Thiago Ferreira ^[1] ; Quinaglia, Thiago ^[1] ; Neilan, Tomas G. ^{[2, 3]} ; Coelho-Filho, Otavio R. ^{[1, 4]}

Affiliation

^[1] Univ Estadual Campinas, Fac Ciencias Med, Rua Tessalia Vieira de Camargo 126, BR-13083887 Campinas, SP - Brazil

^[2] Harvard Med Sch, Massachusetts Gen Hosp, Cardiooncol Program, 55 Fruit St, Boston, MA 02114 - USA

^[3] Harvard Med Sch, Massachusetts Gen Hosp, Cardiac MR PET CT Program, 55 Fruit St, Boston, MA 02114 - USA

^[4] State Univ Campinas UNICAMP, Dept Med, Div Cardiol, Rua Tessalia Vieira de Camargo 126, BR-13083887 Campinas, SP - Brazil

• Document type: Journal article
• Source: MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA; v. 27, n. 3, p. 533+, AUG 2019.
• Web of Science Citations: 0

Abstract

Chemotherapy is associated with cardiovascular injury, including the development of a cardiomyopathy and vascular remodeling. Cardiac magnetic resonance (CMR) is sensitive to detect not only established morphologic and functional abnormalities but also early, potentially reversible, signs of myocardial injury. It robustly detects and quantifies myocardial edema, inflammation, and focal fibrosis, as well as interstitial fibrosis and vascular remodeling. These capabilities support the role of CMR as an excellent tool for evaluating cardiotoxicity. Novel CMR markers may even enhance patient management by facilitating the early detection of reversible myocardial tissue remodeling before classic morphologic and functional changes appear. (AU)

• FAPESP's process: 15/15402-2 - Characterization of interstitial fibrosis and cardiomyocyte hypertrophy by cardiac MRI: implication on early remodeling and on the transition to heart failure
• Grantee: Otávio Rizzi Coelho-Filho
• Support Opportunities: Research Grants - Young Investigators Grants