The role of co-neurotransmitters in sleep and wake regulation

Autor(es)

Oh, Jun ^{[1, 2]} ; Petersen, Cathrine ^{[1, 2]} ; Walsh, Christine M. ^[2] ; Bittencourt, Jackson C. ^{[3, 4]} ; Neylan, Thomas C. ^[5] ; Grinberg, Lea T. ^{[6, 2, 7]}

Afiliação do(s) autor(es)

^[1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 - USA

^[2] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, Weill Inst Neurosci, San Francisco, CA 94143 - USA

^[3] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Ctr Neurosci & Behav, Inst Psychol, Sao Paulo - Brazil

^[5] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA - USA

^[6] Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo - Brazil

^[7] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: MOLECULAR PSYCHIATRY; v. 24, n. 9, p. 1284-1295, SEP 2019.
• Citações Web of Science: 2

Resumo

Sleep and wakefulness control in the mammalian brain requires the coordination of various discrete interconnected neurons. According to the most conventional sleep model, wake-promoting neurons (WPNs) and sleep-promoting neurons (SPNs) compete for network dominance, creating a systematic ``switch{''} that results in either the sleep or awake state. WPNs and SPNs are ubiquitous in the brainstem and diencephalon, areas that together contain <1% of the neurons in the human brain. Interestingly, many of these WPNs and SPNs co-express and co-release various types of the neurotransmitters that often have opposing modulatory effects on the network. Co-transmission is often beneficial to structures with limited numbers of neurons because it provides increasing computational capability and flexibility. Moreover, co-transmission allows subcortical structures to bi-directionally control postsynaptic neurons, thus helping to orchestrate several complex physiological functions such as sleep. Here, we present an in-depth review of co-transmission in hypothalamic WPNs and SPNs and discuss its functional significance in the sleep-wake network. (AU)

• Processo FAPESP: 16/02224-1 - A existência da neurogênese durante o período da lactação
• Beneficiário: Jackson Cioni Bittencourt
• Modalidade de apoio: Auxílio à Pesquisa - Temático