| Full text | |
| Author(s): |
Oh, Jun
[1, 2]
;
Petersen, Cathrine
[1, 2]
;
Walsh, Christine M.
[2]
;
Bittencourt, Jackson C.
[3, 4]
;
Neylan, Thomas C.
[5]
;
Grinberg, Lea T.
[6, 2, 7]
Total Authors: 6
|
| Affiliation: | [1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 - USA
[2] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, Weill Inst Neurosci, San Francisco, CA 94143 - USA
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo - Brazil
[4] Univ Sao Paulo, Ctr Neurosci & Behav, Inst Psychol, Sao Paulo - Brazil
[5] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA - USA
[6] Univ Sao Paulo, Dept Pathol, Med Sch, Sao Paulo - Brazil
[7] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 - USA
Total Affiliations: 7
|
| Document type: | Review article |
| Source: | MOLECULAR PSYCHIATRY; v. 24, n. 9, p. 1284-1295, SEP 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Sleep and wakefulness control in the mammalian brain requires the coordination of various discrete interconnected neurons. According to the most conventional sleep model, wake-promoting neurons (WPNs) and sleep-promoting neurons (SPNs) compete for network dominance, creating a systematic ``switch{''} that results in either the sleep or awake state. WPNs and SPNs are ubiquitous in the brainstem and diencephalon, areas that together contain <1% of the neurons in the human brain. Interestingly, many of these WPNs and SPNs co-express and co-release various types of the neurotransmitters that often have opposing modulatory effects on the network. Co-transmission is often beneficial to structures with limited numbers of neurons because it provides increasing computational capability and flexibility. Moreover, co-transmission allows subcortical structures to bi-directionally control postsynaptic neurons, thus helping to orchestrate several complex physiological functions such as sleep. Here, we present an in-depth review of co-transmission in hypothalamic WPNs and SPNs and discuss its functional significance in the sleep-wake network. (AU) | |
| FAPESP's process: | 16/02224-1 - The existence of neurogenesis during the lactation period |
| Grantee: | Jackson Cioni Bittencourt |
| Support Opportunities: | Research Projects - Thematic Grants |