Apoptotic signaling in salivary mucoepidermoid carcinoma

Autor(es):Mostrar menos -

da Silva, Gabriela M. ^[1] ; Saavedra, Victoria ^[1] ; Ianez, Renata C. F. ^[1] ; de Sousa, Elen A. ^[1] ; Gomes, Agatha N. ^[1] ; Kelner, Natalie ^[2] ; Nagai, Maria A. ^{[3, 4]} ; Kowalski, Luiz P. ^[2] ; Soares, Fernando A. ^{[5, 6]} ; Lourenco, Silvia V. ^[6] ; Coutinho-Camillo, Claudia M. ^[1]

Afiliação do(s) autor(es)

^[1] AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo - Brazil

^[2] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

^[3] Canc Inst Sao Paulo, Ctr Translat Res Oncol, Lab Mol Genet, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Med Sch, Dept Radiol & Oncol, Discipline Oncol, Sao Paulo - Brazil

^[5] Rede DOr Hosp Network, Pathol Div, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 41, n. 9, p. 2904-2913, SEP 2019.
• Citações Web of Science: 0

Resumo

Background Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. Methods The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. Results Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates. Conclusions The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma. (AU)

• Processo FAPESP: 11/02051-6 - Apoptose nas glândulas salivares humanas: avaliação de marcadores na morfogênese e no processo de tumorigênese da glândula utilizando como modelos o adenoma pleomórfico e o carcinoma mucoepidermóide
• Beneficiário: Cláudia Malheiros Coutinho Camillo
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 12/09759-7 - Apoptose nas glândulas salivares humanas: Avaliação de marcadores na morfogênese e no processo de tumorigênese da glândula utilizando como modelos o adenoma pleomórfico e o carcinoma mucoepidermóide
• Beneficiário: Cláudia Malheiros Coutinho Camillo
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores
• Processo FAPESP: 12/20734-6 - Apoptose nas glândulas salivares humanas: Avaliação de marcadores na morfogênese e no processo de tumorigênese da glândula utilizando como modelos o adenoma pleomórfico e o carcinoma mucoepidermóide
• Beneficiário: Gabriela Madureira da Silva
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico