| Full text | |
| Author(s): Show less - |
da Silva, Gabriela M.
[1]
;
Saavedra, Victoria
[1]
;
Ianez, Renata C. F.
[1]
;
de Sousa, Elen A.
[1]
;
Gomes, Agatha N.
[1]
;
Kelner, Natalie
[2]
;
Nagai, Maria A.
[3, 4]
;
Kowalski, Luiz P.
[2]
;
Soares, Fernando A.
[5, 6]
;
Lourenco, Silvia V.
[6]
;
Coutinho-Camillo, Claudia M.
[1]
Total Authors: 11
|
| Affiliation: | [1] AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo - Brazil
[2] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
[3] Canc Inst Sao Paulo, Ctr Translat Res Oncol, Lab Mol Genet, Sao Paulo - Brazil
[4] Univ Sao Paulo, Med Sch, Dept Radiol & Oncol, Discipline Oncol, Sao Paulo - Brazil
[5] Rede DOr Hosp Network, Pathol Div, Sao Paulo - Brazil
[6] Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 41, n. 9, p. 2904-2913, SEP 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. Methods The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. Results Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates. Conclusions The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma. (AU) | |
| FAPESP's process: | 11/02051-6 - Apoptosis in human salivary glands: evaluation of markers during the morphogenesis and tumorigenesis of human salivary glands using pleomorphic adenoma and mucoepidermoid carcinoma as models |
| Grantee: | Cláudia Malheiros Coutinho Camillo |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 12/09759-7 - Apoptosis in human salivary glands: Evaluation of markers during the morphogenesis and tumorigenesis of human salivary glands using pleomorphic adenoma and mucoepidermoid carcinoma as models |
| Grantee: | Cláudia Malheiros Coutinho Camillo |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 12/20734-6 - Apoptose nas glândulas salivares humanas: Avaliação de marcadores na morfogênese e no processo de tumorigênese da glândula utilizando como modelos o adenoma pleomórfico e o carcinoma mucoepidermóide |
| Grantee: | Gabriela Madureira da Silva |
| Support Opportunities: | Scholarships in Brazil - Technical Training Program - Technical Training |