Apoptotic signaling in salivary mucoepidermoid carcinoma

Author(s):Show less -

da Silva, Gabriela M. ^[1] ; Saavedra, Victoria ^[1] ; Ianez, Renata C. F. ^[1] ; de Sousa, Elen A. ^[1] ; Gomes, Agatha N. ^[1] ; Kelner, Natalie ^[2] ; Nagai, Maria A. ^{[3, 4]} ; Kowalski, Luiz P. ^[2] ; Soares, Fernando A. ^{[5, 6]} ; Lourenco, Silvia V. ^[6] ; Coutinho-Camillo, Claudia M. ^[1]

Affiliation

^[1] AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo - Brazil

^[2] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil

^[3] Canc Inst Sao Paulo, Ctr Translat Res Oncol, Lab Mol Genet, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Med Sch, Dept Radiol & Oncol, Discipline Oncol, Sao Paulo - Brazil

^[5] Rede DOr Hosp Network, Pathol Div, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Dent Sch, Dept Gen Pathol, Sao Paulo - Brazil

• Document type: Journal article
• Source: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 41, n. 9, p. 2904-2913, SEP 2019.
• Web of Science Citations: 0

Abstract

Background Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. Apoptosis plays an important role in organogenesis of glandular structures, and aberrations of apoptotic mechanisms is associated with a wide array of pathologic conditions. Methods The immunoexpression of proteins associated with apoptosis and proliferation was evaluated in 40 mucoepidermoid carcinoma cases. Results Par-4, Survivin, MUC1, PHLDA1, Fas, and Ki-67 were predominantly expressed in mucoepidermoid carcinoma. FasL was rarely expressed, and Caspase-3 expression was observed in almost 50% of the cases. SPARC expression was associated with low-grade tumors, and Ki-67 expression was associated with lymph node metastasis. Expression of Fas and decreased expression of Ki-67 and Caspase-3 were associated with better overall cancer-specific survival rates. Conclusions The association of SPARC and Ki-67 expression with pathological features and the association of Fas, Caspase-3, and Ki-67 with survival probabilities suggest that these proteins may be useful prognostic markers for mucoepidermoid carcinoma. (AU)

• FAPESP's process: 11/02051-6 - Apoptosis in human salivary glands: evaluation of markers during the morphogenesis and tumorigenesis of human salivary glands using pleomorphic adenoma and mucoepidermoid carcinoma as models
• Grantee: Cláudia Malheiros Coutinho Camillo
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 12/09759-7 - Apoptosis in human salivary glands: Evaluation of markers during the morphogenesis and tumorigenesis of human salivary glands using pleomorphic adenoma and mucoepidermoid carcinoma as models
• Grantee: Cláudia Malheiros Coutinho Camillo
• Support Opportunities: Scholarships in Brazil - Young Researchers