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Exploring the exome of salivary mucoepidermoid carcinoma in search of more accurate prognostic markers

Grant number: 14/07249-7
Support type:Regular Research Grants
Duration: August 01, 2014 - July 31, 2017
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Luiz Paulo Kowalski
Grantee:Luiz Paulo Kowalski
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Assoc. researchers:Diana Noronha Nunes ; Emmanuel Dias-Neto

Abstract

Mucoepidermoid carcinoma of salivary gland (CMGS) have a great variability in thebiological behavior and its treatment depends both clinical and pathological prognosticfactors. One the most well-established prognostic factors for CMGS is the histological gradeof malignancy, which represents the morphological grading of tumor biologicalcharacteristics, despite its subjectivity, has proved to be important in determining tumorbehavior. However, some of these tumors are classified as intermediate grade - aheterogeneous group where the behavior can be similar to low-grade, or aggressive as highgradetumors. Clearly , the traditional parameters based on morphological characteristics ofthe cells and tissues are not accurate enough to allow an adequate prognostic classification ofthese tumors, often leading to inappropriate treatment. In this sense, molecular tools can helpgenerate information of predictive and prognostic value, and can also identify new therapeutictargets. Molecular assessment of the CMGS exome can help identify genetic variants as DNApolymorphisms, mutations, chromosomal rearrangements, among others, which can assist thehistological grading based on differences and similarities among these tumors. In this regard,the alterations found in the DNA of these tumors may lead to more accurate diagnosis andconsequently the choice of a more appropriate therapeutic conduct. (AU)