Extracellular vesicles and its advances in female reproduction

Autor(es)

Cavalcante Mendes de Avila, Ana Clara Faquineli ^[1] ; Andrade, Gabriella Mamede ^[1] ; Bridi, Alessandra ^[1] ; Gimenes, Lindsay Unno ^[2] ; Meirelles, Flavio Vieira ^[1] ; Perecin, Felipe ^[1] ; da Silveira, Juliano Coelho ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Pirassununga, SP - Brazil

^[2] Sao Paulo State Univ Unesp, Sch Agr & Vet Sci, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ANIMAL REPRODUCTION; v. 16, n. 1, p. 31-38, JAN-MAR 2019.
• Citações Web of Science: 1

Resumo

Intercellular communication is an essential mechanism for development and maintenance of multicellular organisms. Extracellular vesicles (EVs) were recently described as new players in the intercellular communication. EVs are double-membrane vesicles secreted by cells and are classified according to their biosynthesis, protein markers and morphology. These extracellular vesicles contain bioactive materials such as miRNA, mRNA, protein and lipids. These characteristics permit their involvement in different biological processes. Reproductive physiology is complex and involves constant communication between cells. Different laboratories have described the presence of EVs secreted by ovarian follicular cells, oviductal cells, in vitro produced embryos and by the endometrium, suggesting that EVs are involved in the development of gametes and embryos, in animals and humans. Therefore, is important to understand physiological mechanisms and contributions of EVs in female reproduction in order to develop new tools to improve in vivo reproductive events and assisted reproductive techniques (ARTs). This review will provide the current knowledge related to EVs in female reproductive tissues and their role in ARTs. (AU)

• Processo FAPESP: 18/01431-9 - Efeito da via de sinalização PI3K-Akt na maturação oocitária e no desenvolvimento embrionário inicial em bovinos
• Beneficiário: Gabriella Mamede Andrade
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/02037-0 - Descrição de um novo mecanismo de comunicação celular entre células do sistema reprodutivo feminino e oócito mediado por vesículas extracelulares e seus impactos na maturação de oócitos, fertilização e a clivagem de embriões bovinos
• Beneficiário: Ana Clara Faquineli Cavalcante Mendes de Ávila
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 14/22887-0 - Exossomos e microvesículas contendo miRNAs modulam mudanças epigenéticas durante o cultivo in vitro de gametas e embriões em bovinos
• Beneficiário: Juliano Coelho da Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores