Distribution of local ancestry and evidence of adaptation in admixed populations

Autor(es):Mostrar menos -

Secolin, Rodrigo ^{[1, 2, 3]} ; Mas-Sandoval, Alex ^{[4, 3]} ; Arauna, Lara R. ^[3] ; Torres, Fabio R. ^{[1, 2]} ; de Araujo, Tania K. ^{[1, 2]} ; Santos, Marilza L. ^{[1, 2]} ; Rocha, Cristiane S. ^{[1, 2]} ; Carvalho, Benilton S. ^{[1, 5]} ; Cendes, Fernando ^{[6, 1]} ; Lopes-Cendes, Iscia ^{[1, 2]} ; Comas, David ^[3]

Afiliação do(s) autor(es)

^[1] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Dept Med Genet & Genom Med, Campinas, SP - Brazil

^[3] Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Ciencies Expt & Salut, Barcelona - Spain

^[4] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS - Brazil

^[5] Univ Campinas UNICAMP, Inst Math Stat & Sci Comp, Dept Stat, Campinas, SP - Brazil

^[6] Univ Campinas UNICAMP, Dept Neurol, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 9, SEP 25 2019.
• Citações Web of Science: 0

Resumo

Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events. (AU)

• Processo FAPESP: 13/07559-3 - Instituto Brasileiro de Neurociência e Neurotecnologia - BRAINN
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/14423-9 - Estudando a estrutura genética da população de uma região geográfica específica: um estudo comparativo usando variantes comuns, raras e estruturais.
• Beneficiário: Rodrigo Secolin
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado