Unusual presentation of a disseminated oral HPV infection after combined antiretroviral therapy initiation

Autor(es)

Daniela Assis do Vale ^[1] ; Lais Magda Araújo Ferracini ^[2] ; Marcus Vinícius da Silva Rodrigues Bueno ^[3] ; Ana Carolina Mamana Fernandes Souza ^[4] ; Paulo Henrique Braz-Silva ; Karem López Ortega ^[6]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Faculdade de Odontologia. Departamento de Estomatologia - Brasil

^[2] Universidade de São Paulo. Faculdade de Odontologia. Departamento de Estomatologia - Brasil

^[3] Universidade de São Paulo. Faculdade de Odontologia. Departamento de Estomatologia - Brasil

^[4] Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo. Laboratório de Virologia - Brasil

^[6] Universidade de São Paulo. Faculdade de Odontologia. Departamento de Estomatologia - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Revista do Instituto de Medicina Tropical de São Paulo; v. 61, 2019-10-10.

Resumo

ABSTRACT HPV clinical manifestations have their characteristics modified by the use of combined antiretroviral therapy (cART), although its incidence is unaffected by cART. We report an unusual presentation of oral HPV infection and discuss an effective treatment for disseminated HPV lesions. A 52-year-old male of Asian-origin, HIV-seropositive, presented with extensive nodular lesions throughout the oral mucosa extending to the oropharyngeal region. Biopsy followed by histopathological examination and HPV genotyping were performed. The treatment was initiated with topical application of podophyllin and trichloroacetic acid. HPV lesions in oral mucosa are generally easy to handle. Extensive lesions can make it difficult to choose an effective treatment that meets the patient’s particularities and medication availability. (AU)

• Processo FAPESP: 15/07727-9 - Avaliação do ambiente imunoregulatório de lesões potencialmente malignas de boca, carcinomas de boca e orofaringe relacionados ou não ao HPV.
• Beneficiário: Paulo Henrique Braz da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular