Advanced Glycation Endproducts as Biomarkers for Risk of Diabetes and Cardiovascular Diseases by Skin Autofluorescence: A Noninvasive Optical Screening

Autor(es)

Paolillo, Fernanda Rossi ^[1] ; Mattos, Vicente Silva ^[1] ; Borghi-Silva, Audrey ^[2] ; Bagnato, Vanderlei Salvador ^[1] ; de Castro Neto, Jarbas Caiado ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sao Carlos Inst Phys IFSC, Opt Grp, Ave Trabalhador Saocarlense 400, BR-13560970 Sao Carlos, SP - Brazil

^[2] Fed Univ Sao Carlos UFSCar, Dept Phys Therapy, Cardiopulm Physiotherapy Lab, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY; v. 37, n. 3, p. 168-174, MAR 2019.
• Citações Web of Science: 0

Resumo

Objective: The aim of this research is to study skin autofluorescence and the associations between skin glycated proteins and clinical characteristics of healthy and unhealthy subjects for noninvasive screening of diabetes and cardiovascular disease (CVD) risks. Background data: Accumulated advanced glycation endproducts (AGEs) promote increased oxidative stress and inflammation, as well as cross-linking of proteins leading to tissue damage and several diseases, including diabetes. Materials and methods: One hundred and four subjects with or without diabetes and stroke aged 20-80 years and with Fitzpatrick skin type (I to IV) participated in this study. The fluorescence spectrometer was used to illuminate a skin surface of 1 cm2. The skin of forearm was positioned on the spectrometer to assess skin AGEs. Anthropometric data and body composition also were evaluated. Results: Elevated skin autofluorescence was found in subjects > 50 years old, as well as in patients with insulin resistance (IR), diabetes, and stroke. There was a positive correlation between the skin autofluorescence and age (r = 0.7, p = 0.0001), body mass index (BMI) (r = 0.5, p = 0.001), body fat (r = 0.5, p = 0.0001), waist circumference (r = 0.45, p = 0.001), and systolic blood pressure (BP) (r = 0.45, p = 0.0001). Conclusions: Elevated skin autofluorescence can provide a noninvasive screening of diabetes and CVD risks. (AU)

• Processo FAPESP: 13/14001-9 - Espectroscopia de fluorescência em dentes de ratas ovariectomizadas para o diagnóstico da osteoporose
• Beneficiário: Fernanda Rossi Paolillo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07276-1 - CEPOF - Centro de Pesquisa em Óptica e Fotônica
• Beneficiário: Vanderlei Salvador Bagnato
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs