| Texto completo | |
| Autor(es): |
Santos, Talita de Mello
[1]
;
Cavariani, Marilia Martins
[1]
;
Pereira, Dhrielly Natalia
[1]
;
Schimming, Bruno Cesar
[1]
;
de Almeida Chuffa, Luiz Gustavo
[1]
;
Domeniconi, Raquel Fantin
[1]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ UNESP, Inst Biosci, Dept Anat, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CELLS; v. 8, n. 9 SEP 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
The maternal nutritional status is essential to the health and well-being of the fetus. Maternal protein restriction during the perinatal stage causes sperm alterations in the offspring that are associated with epididymal dysfunctions. Vascular endothelial growth factor (VEGF) and its receptor, VEGFr-2, as well as aquaporins (AQPs) are important regulators of angiogenesis and the epididymal microenvironment and are associated with male fertility. We investigated the effects of maternal protein restriction on epididymal angiogenesis and AQP expression in the early stages of postnatal epididymal development. Pregnant rats were divided into two experimental groups that received either a normoprotein (17% protein) or low-protein diet (6% protein) during gestation and lactation. At postnatal day (PND)7 and PND14, male offspring were euthanized, the epididymides were subjected to morphometric and microvascular density analyses and to VEGF-A, VEGF-r2, AQP1 and AQP9 expression analyses. The maternal low-protein diet decreased AQP9 and VEGFr-2 expression, decreased epididymal microvascularity and altered the morphometric features of the epididymal epithelium; no changes in AQP1 expression were observed at the beginning of postnatal epididymal development. Maternal protein restriction alters microvascularization and affects molecules involved in the epidydimal microenvironment, resulting in morphometric alterations related to a delay in the beginning of epididymis postnatal development. (AU) | |
| Processo FAPESP: | 16/04085-9 - Desenvolvimento do ducto de Wolffian, diferenciação e padrão vascular do epidídimo de ratos Wistar expostos à restrição proteica durante a gestação e lactação |
| Beneficiário: | Raquel Fantin Domeniconi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/23953-4 - Análise de fatores de crescimento no epidídimo de ratos cujas mães foram submetidas à restrição protéica durante a gestação e lactação |
| Beneficiário: | Dhrielly Natalia Pereira |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 15/18767-1 - Efeitos da restrição proteica materna sobre o padrão vascular e expressão de proteínas no epidídimo de ratos Wistar machos em diferentes fases do desenvolvimento pós-natal |
| Beneficiário: | Marilia Martins Cavariani |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |