Laryngeal Epstein-Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child

Autor(es)

Soares, Ciro Dantas ^[1] ; Carlos, Roman ^[2] ; Diaz Molina, Juan Pablo ^[2] ; de Lima Morais, Thayna Melo ^[1] ; de Almeida, Oslei Paes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Pathol, Av Limeira 901, POB 52, BR-13414903 Piracicaba, SP - Brazil

^[2] Hosp Herrera Llerandi, Ctr Clinico Cabeza & Cuello, Guatemala City - Guatemala

• Tipo de documento: Artigo Científico
• Fonte: Head and Neck Pathology; v. 13, n. 4, p. 722-726, DEC 2019.
• Citações Web of Science: 0

Resumo

Smooth muscle tumors associated with Epstein-Barr virus infections (EBV-SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for alpha-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author's knowledge, this is the first literature-reported case of laryngeal EBV-SMT occurring in an undernourished child. (AU)

• Processo FAPESP: 15/25905-1 - Expressão de Akt, COX-2, RUNX1 e metaloproteinases em melanomas metastáticos e Prospecção biotecnológica de moléculas com atividade antitumoral
• Beneficiário: Ciro Dantas Soares
• Modalidade de apoio: Bolsas no Brasil - Doutorado