Laryngeal Epstein-Barr Virus-Associated Smooth Muscle Tumor in an Undernourished Child

Author(s)

Soares, Ciro Dantas ^[1] ; Carlos, Roman ^[2] ; Diaz Molina, Juan Pablo ^[2] ; de Lima Morais, Thayna Melo ^[1] ; de Almeida, Oslei Paes ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Piracicaba Dent Sch, Oral Pathol, Av Limeira 901, POB 52, BR-13414903 Piracicaba, SP - Brazil

^[2] Hosp Herrera Llerandi, Ctr Clinico Cabeza & Cuello, Guatemala City - Guatemala

• Document type: Journal article
• Source: Head and Neck Pathology; v. 13, n. 4, p. 722-726, DEC 2019.
• Web of Science Citations: 0

Abstract

Smooth muscle tumors associated with Epstein-Barr virus infections (EBV-SMT) of laryngeal origin are exceedingly rare and have been reported in few adult patients, but not in children. This reported case describes a lesion found in the larynx of an 8-year-old Guatemalan undernourished girl. Microscopically, the lesion showed a highly cellular mesenchymal spindle cell tumor, containing frequent lymphocytes. The immunohistochemical analysis revealed positivity for alpha-smooth muscle actin and h-caldesmon. In addition, most of the tumor cells were positive for EBV by in situ hybridization. To the best of the author's knowledge, this is the first literature-reported case of laryngeal EBV-SMT occurring in an undernourished child. (AU)

• FAPESP's process: 15/25905-1 - Akt, COX-2, RUNX1 and MMPs expression in metastatic melanomas and Biotechnology prospection of molecules with antineoplastic activity
• Grantee: Ciro Dantas Soares
• Support Opportunities: Scholarships in Brazil - Doctorate