Coupling Single-Drop Microextraction with SERS: A Demonstration Using p-MBA on Gold Nanohole Array Substrate

Autor(es)

Santos, Elias B. ^[1] ; Valsecchi, Chiara ^[2] ; Goncalves, Jaderson L. S. ^[2] ; Avila, Luis F. ^[3] ; Menezes, Jacson W. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, LQANano, BR-12231280 Sao Jose Dos Campos, SP - Brazil

^[2] Fed Univ Pampa, Engn Dept, BR-97546550 Alegrete, RS - Brazil

^[3] Univ Estadual Campinas, Sch Technol, Appl Opt Lab, BR-13484350 Limeira, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SENSORS; v. 19, n. 20 OCT 2 2019.
• Citações Web of Science: 0

Resumo

Single-drop microextraction (SDME) was coupled with surface-enhanced Raman scattering (SERS) to provide sample extraction and pre-concentration for detection of analyte at low concentrations. A gold nanohole array substrate (AuNHAS), fabricated by interference lithography, was used as SERS substrate and para-mercaptobenzoic acid (p-MBA) was tested as a probe molecule, in the concentration range 10(-8)-10(-4) mol L-1. With this approach, a limit of 10(-7) mol L-1 was clearly detected. To improve the detection to lower p-MBA concentration, as 10(-8) mol L-1, the SDME technique was applied. The p-MBA Raman signature was detected in two performed extractions and its new concentration was determined to be similar to 4.6 x 10(-5) mol L-1. This work showed that coupling SDME with SERS allowed a rapid (5 min) and efficient pre-concentration (from 10 8 mol L-1 to 10(-5) mol L-1), detection, and quantification of the analyte of interest, proving to be an interesting analytical tool for SERS applications. (AU)

• Processo FAPESP: 15/16573-5 - Nanopartículas plasmônicas de prata, ouro e cobre: métodos de síntese, preparação de sensores plasmônicos e SERS reprodutíveis para aplicações na área ambiental
• Beneficiário: Elias de Barros Santos
• Modalidade de apoio: Auxílio à Pesquisa - Regular